Hypoestrogenism does not mediate social suppression of cortisol in subordinate female marmosets.
Hypoestrogenism does not mediate social suppression of cortisol in subordinate female marmosets.
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雌激素水平低下并不会介导从属雌性狨猴体内皮质醇的社会抑制。
DOI：
10.1016/j.psyneuen.2006.01.006
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发表时间：
2006
影响因子：
3.7
通讯作者：
Abbott,DavidH
中科院分区：
文献类型：
--
作者：
Saltzman,Wendy;Hogan,BrynnK;Allen,AmyJ;Horman,BrianM;Abbott,DavidH
行为从属的雌性狨猴经历了排卵和雌激素分泌减少的社会抑制，以及循环基础皮质醇浓度的慢性降低。由于雌性激素在其他物种中会提高下丘脑-垂体-肾上腺轴的活性和循环糖皮质激素水平，因此我们验证了社会诱导的雌性低雌激素水平有助于下属雌性狨猴皮质醇降低的假设。我们研究了7名不排卵女性和6名去卵巢的非隶属女性在两种条件下的早晨基础血浆皮质醇水平，以及皮质醇对外源性促肾上腺皮质激素（ACTH； 0、1或10μg/kg）的反应：长期使用雌二醇（E2）治疗和对照组。将循环e2和皮质醇水平与6个处于排卵期的优势雌性进行比较。在对照条件下，下属的基础皮质醇浓度明显低于显性和去卵巢的雌性。e2治疗将下属和去卵巢雌性的循环e2水平升高到优势雌性的范围内，但没有增加平均基础或acth刺激的皮质醇水平。相反，随着时间的推移，e2治疗导致基础皮质醇水平下降，尤其是在切除卵巢的动物中。这些结果表明，外源性雌激素治疗不会提高先前低雌激素雌性狨猴的循环皮质醇水平，相应地，社会诱导的低雌激素雌性也不会降低下属雌性的皮质醇水平。
Behaviorally subordinate female marmosets undergo social suppression of ovulation and hypoestrogenism, as well as chronic reductions in circulating basal cortisol concentrations. Because estrogen elevates hypothalamic–pituitary–adrenal axis activity and circulating glucocorticoid levels in other species, we tested the hypothesis that socially induced hypoestrogenism contributes to cortisol reductions in subordinate female marmosets. We characterized morning basal plasma cortisol levels, as well as cortisol responses to exogenous adrenocorticotropic hormone (ACTH; 0, 1, or 10μg/kg), in seven anovulatory subordinate females and six ovariectomized, non-subordinate females under two conditions: during long-term treatment with estradiol (E2) and control. Circulating E2and cortisol levels were compared to those of six dominant females undergoing ovulatory cycles. Basal cortisol concentrations in the control condition were significantly lower in subordinates than in both dominant and ovariectomized females. E2treatment elevated circulating E2levels of subordinate and ovariectomized females into the range seen in dominant females but did not increase either mean basal or ACTH-stimulated cortisol levels. To the contrary, E2treatment caused a decline in basal cortisol levels over time, especially in ovariectomized animals. These results indicate that treatment with exogenous estrogen does not elevate circulating cortisol levels in previously hypoestrogenemic female marmosets and, correspondingly that socially induced hypoestrogenism does not diminish cortisol levels in subordinate females.