Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study.
Body Fatness, Adipose Tissue Compartments, and Biomarkers of Inflammation and Angiogenesis in Colorectal Cancer: The ColoCare Study.
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DOI：
10.1158/1055-9965.epi-18-0654
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Ulrich CM
中科院分区：
文献类型：
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作者：
Himbert C;Ose J;Nattenmüller J;Warby CA;Holowatyj AN;Böhm J;Lin T;Haffa M;Gigic B;Hardikar S;Scherer D;Zielske L;Schrotz-King P;Kölsch T;Siegel EM;Shibata D;Ulrich A;Schneider M;Hursting SD;Kauczor HU;Ulrich CM
肥胖与结直肠癌的风险和预后有关;然而，不同脂肪区域[内脏（VFA）与皮下脂肪区域（SFA）]的影响尚不清楚。我们研究了结直肠癌患者肥胖与炎症和血管生成生物标志物之间的关系。术前血清样本和计算机断层扫描从188例诊断为原发性浸润性I-IV期结直肠癌的患者中获得，这些患者参加了ColoCare研究。通过基于面积的VFA、SFA和VFA：SFA比率在脊柱水平L3/L4和L4/L5上的定量来评估肥胖。在Meso-Scale-Discoveries平台上从患者血清评估炎症（CRP、SAA、sICAM-1、sVCAM-1）和血管生成（VEGF-A、VEGF-D）的循环水平。偏相关和回归分析，调整年龄，性别和肿瘤分期，进行。VFA与CRP和SAA中度相关（CRP：L3/L4和L4/L5：r=0.21，p=0.01; SAA：L3/L4：r=0.17，p=0.04）。SFA与测量的生物标志物之间的相关性较弱（r≤0.13，不显著）。L3/L4的VFA：SFA比值与VEGF-A（r=0.28，p=0.0008）和SAA（r=0.24，p=0.006）中度相关，与CRP（r=0.18，p=0.04）和sICAM-1（r=0.18，p=0.04）相关性较低。在L4/L5的VFA：SFA比率中发现了类似的相关性。我们观察到内脏肥胖与结直肠癌患者的炎症和血管生成生物标志物之间的关联。特别是，VFA：SFA比率与促血管生成生物标志物VEGF-A的循环水平相关。我们的研究结果支持内脏脂肪组织与炎症和血管生成过程直接相关，这些过程在结直肠癌的发展和进展中起着重要作用。
Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients with colorectal cancer. Preoperative serum samples and computed tomography scans were obtained from 188 patients diagnosed with primary invasive stage I-IV colorectal cancer enrolled in the ColoCare Study. Adiposity was assessed by area-based quantification of VFA, SFA, and VFA:SFA ratio on spinal levels L3/L4 and L4/L5. Circulating levels of inflammation (CRP, SAA, sICAM-1, sVCAM-1) and angiogenesis (VEGF-A, VEGF-D) were assessed from patient sera on the Meso-Scale-Discoveries platform. Partial correlations and regression analyses, adjusted for age, sex, and tumor stage, were performed. VFA was moderately correlated with CRP and SAA (CRP: L3/L4 and L4/L5:r=0.21, p=0.01; SAA: L3/L4:r=0.17, p=0.04). The correlation between SFA and the measured biomarkers were weak (r≤0.13, not significant). The ratio of VFA:SFA at L3/L4 was moderately correlated with VEGF-A (r=0.28, p=0.0008), and SAA (r=0.24, p=0.006), and less so with CRP (r=0.18, p=0.04) and sICAM-1 (r=0.18, p=0.04). Similar correlations were found for VFA:SFA ratio at L4/L5. We observed an association between visceral adiposity and biomarkers of inflammation and angiogenesis in colorectal cancer patients. In particular, the VFA:SFA ratio was correlated with circulating levels of pro-angiogenic biomarker VEGF-A. Our findings support a direct association of visceral adipose tissue with inflammatory and angiogenic processes, which play fundamental roles in the development and progression of colorectal cancer.