Muscle changes in amyotrophic lateral sclerosis: A longitudinal ultrasonography study
Muscle changes in amyotrophic lateral sclerosis: A longitudinal ultrasonography study
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DOI：
10.1016/j.clinph.2010.07.023
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发表时间：
2011-03-01
影响因子：
4.7
通讯作者：
Zwarts, Machiel J.
中科院分区：
文献类型：
--
作者：
Arts, Ilse M. P.;Overeem, Sebastiaan;Zwarts, Machiel J.
目的：我们进行了一项纵向研究，以评估肌萎缩侧索硬化症（ALS）的结构性肌肉变化，使用超声检查。对31例ALS患者的6个肌群进行肌层厚度、回声强度和肌束震颤的测量，并对肌层厚度、回声强度和肌束震颤进行评分，结果：在基线时，我们发现回声强度增加，厚度减少，这些参数与较低的强度相关。此外，在保留力量的肌肉中也检测到超声异常。回声强度、肌肉厚度和肌束震颤的纵向变化在患者之间表现出很大的差异。超声参数的变化率与ALSFRS-R或strength.Conclusion的变化不相关：在ALS患者中，超声异常可以发现在肌肉与保存的力量。ALS的超声检查肌肉变化的模式是高度可变的，并没有表现出明显的相关性与功能measurements.Significance：超声检查是不适合监测ALS的疾病进展。(C)2010年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: We performed a longitudinal study to assess structural muscle changes in amyotrophic lateral sclerosis (ALS) using ultrasonography.Methods: During a follow-up of 6 months, ultrasonography parameters (muscle thickness, echo intensity and fasciculations) were obtained from 6 muscle groups in 31 ALS patients, together with strength and scores on the revised ALS functional rating scale (ALSFRS-r).Results: At baseline, we found an increased echo intensity and decreased thickness, and these parameters correlated with lower strength. Moreover, ultrasound abnormalities were also detected in muscles with preserved strength. Longitudinal changes in echo intensity, muscle thickness and fasciculations showed large variations between patients. Rates of change in ultrasound parameters did not correlate with changes in ALSFRS-r or strength.Conclusion: In patients with ALS ultrasound abnormalities can be found in muscles with preserved strength. The pattern of ultrasonographic muscle changes in ALS is highly variable and shows no evident correlation with functional measures.Significance: Ultrasonography is not suitable to monitor disease progression in ALS. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.