Nanotechnology for enrichment and detection of circulating tumor cells.
Nanotechnology for enrichment and detection of circulating tumor cells.
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DOI：
10.2217/nnm.15.32
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Bhana S;Wang Y;Huang X
循环肿瘤细胞（CTC）是癌症侵袭行为的标志，负责转移的发展。它们的检测和分析在癌症生物学和临床实践中具有重要影响。然而，CTC是罕见的事件，并且包含异质亚群，需要高度敏感和特异性的技术来高效地鉴定和捕获CTC。由于纳米材料独特的结构和功能特性，纳米技术在CTC富集和检测方面显示出强大的前景。在这篇综述中，我们讨论了基于各种功能纳米系统和纳米结构基底的CTC富集和检测技术，目的是突出纳米技术在基础和临床CTC研究中的作用。
Circulating tumor cells (CTCs) are a hallmark of invasive behavior of cancer, responsible for the development of metastasis. Their detection and analysis have significant impacts in cancer biology and clinical practice. However, CTCs are rare events and contain heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and capture CTCs with high efficiency. Nanotechnology shows strong promises for CTC enrichment and detection owning to the unique structural and functional properties of nanoscale materials. In this review, we discuss the CTC enrichment and detection technologies based on a variety of functional nanosystems and nanostructured substrates, with the goal to highlight the role of nanotechnology in the advancement of basic and clinical CTC research.