Quiet Submillimeter MR Imaging of the Lung Is Feasible with a PETRA Sequence at 1.5 T
Quiet Submillimeter MR Imaging of the Lung Is Feasible with a PETRA Sequence at 1.5 T
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DOI：
10.1148/radiol.15141655
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发表时间：
2015-07-01
期刊：
影响因子：
19.7
通讯作者：
Laurent, Francois
中科院分区：
文献类型：
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作者：
Dournes, Gael;Grodzki, David;Laurent, Francois
目的：评价1.5T呼吸门控逐点编码时间缩减径向采集(PETRA)序列的肺磁共振(MR)成像，并与标准体积内插式屏气检查(VIBE)序列进行比较，重点是支气管的可见性和肺实质的信号强度。材料和方法：本研究由当地伦理委员会批准，所有受试者均给予书面知情同意。12名健康志愿者接受了Petra和Vibe序列的成像。图像质量通过视觉评分、可见支气管数、表观对比噪声比(CNR)和信噪比(SNR)的定量测量来评价。在初步的临床评估中，三名年轻的囊性纤维化患者同时接受了磁共振成像和计算机断层扫描(CT)。比较是通过使用均值的Wilcoxon符号等级检验和比率的McNemar检验来进行的。结果：采用体素大小为0.86 mm(3)的PETRA成像。整体图像质量较好，运动伪影较少。直到第四代，在某些情况下，一直到第六代，都能看到支气管的存在。PETRA的平均信噪比和信噪比分别比VIBE高32.4%+/-7.6%(标准差)和322.2%+/-37.9.CT和PETRA囊性纤维化评分(kappa=1.0)之间有很好的一致性。结论：PETRA能够以较高的CNR和SNR对支气管和肺实质进行无声、自由呼吸、各向同性和亚毫米成像，可能是囊性纤维化患者CT的替代方法。
Purpose: To assess lung magnetic resonance (MR) imaging with a respiratory-gated pointwise encoding time reduction with radial acquisition (PETRA) sequence at 1.5 T and compare it with imaging with a standard volumetric interpolated breath-hold examination (VIBE) sequence, with extra focus on the visibility of bronchi and the signal intensity of lung parenchyma.Materials and Methods: The study was approved by the local ethics committee, and all subjects gave written informed consent. Twelve healthy volunteers were imaged with PETRA and VIBE sequences. Image quality was evaluated by using visual scoring, numbering of visible bronchi, and quantitative measurement of the apparent contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR). For preliminary clinical assessment, three young patients with cystic fibrosis underwent both MR imaging and computed tomography (CT). Comparisons were made by using the Wilcoxon signed-rank test for means and the McNemar test for ratios. Agreement between CT and MR imaging disease scores was assessed by using the kappa test.Results: PETRA imaging was performed with a voxel size of 0.86 mm(3). Overall image quality was good, with little motion artifact. Bronchi were visible consistently up to the fourth generation and in some cases up to the sixth generation. Mean CNR and SNR with PETRA were 32.4% +/- 7.6 (standard deviation) and 322.2% +/- 37.9, respectively, higher than those with VIBE (P < .001). Good agreement was found between CT and PETRA cystic fibrosis scores (kappa = 1.0).Conclusion: PETRA enables silent, free-breathing, isotropic, and submillimeter imaging of the bronchi and lung parenchyma with high CNR and SNR and may be an alternative to CT for patients with cystic fibrosis.