Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease.
Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease.
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DOI：
10.1002/cpt.418
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发表时间：
2016-11
影响因子：
6.7
通讯作者：
Morris ME
中科院分区：
文献类型：
--
作者：
Jones RS;Morris ME
溶质载体(SLC)转运蛋白代表了52个膜转运蛋白家族，它们在内源性复合动态平衡和异种生物处置中发挥作用，并已被用于药物输送和治疗靶向策略。特别是，编码单羧酸转运体(MCT)家族14种异构体的SLC16家族在内源性和外源性化合物的吸收、组织分布和清除中发挥着重要作用。巨噬细胞集落刺激因子是运输细胞基本营养物质以及调节细胞代谢和pH所必需的。最近的出版物指出了它们在疾病中的新作用，因此它们作为疾病生物标记物和新的治疗靶点的潜力正在研究中。对MCT异构体的功能、特异性、表达和调控进行更多的研究，将使研究人员能够挖掘MCT作为疾病治疗靶点和预后因子在临床上的潜在用途。
Solute carrier (SLC) transporters represent 52 families of membrane transport proteins that function in endogenous compound homeostasis and xenobiotic disposition, and have been exploited in drug delivery and therapeutic targeting strategies. In particular, the SLC16 family that encodes for the 14 isoforms of the monocarboxylate transporter (MCT) family plays a significant role in the absorption, tissue distribution, and clearance of both endogenous and exogenous compounds. MCTs are required for the transport of essential cell nutrients and for cellular metabolic and pH regulation. Recent publications have indicated their novel roles in disease, and thus their potential as biomarkers and new therapeutic targets in disease are under investigation. More research into MCT isoform function, specificity, expression, and regulation will allow researchers to exploit the potential utility of MCTs in the clinic as therapeutic targets and prognostic factors of disease.
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影响因子：
5.7
作者：
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通讯作者：
Stratford IJ
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Ushijima, T
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通讯作者：
Philp, Nancy J.
影响因子：
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作者：
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通讯作者：
Refetoff, S