Anti-inflammatory properties of triblock siloxane copolymer-blended materials.
Anti-inflammatory properties of triblock siloxane copolymer-blended materials.
复制标题
DOI：
10.1016/s0142-9612(99)00034-4
复制
发表时间：
1999-08
期刊：
影响因子：
14
通讯作者：
L. Tang;M. Sheu;T. Chu;Y. Huang
中科院分区：
文献类型：
--
作者：
L. Tang;M. Sheu;T. Chu;Y. Huang
植入性生物材料经常引发各种不良反应。由于聚二甲基硅氧烷表面具有良好的血液相容性和生物相容性，因此通常认为可以通过用类似硅酮的性质改性生物材料表面来改善表面生物相容性。为此，我们开发了一系列聚己内酯-聚二甲基硅氧烷-聚己内酯（PDMS-PCL）共聚物。通过将基材-聚氯乙烯-与低浓度（1.2和2.4%）的PDMS-PCL共聚物混合，我们产生了具有类似有机硅的表面性质的材料，如通过增加的表面硅含量和表面接触角所反映的。我们在体外评估了这些表面的生物相容性，发现PDMS-PCL的加入显著降低了表面“变性”纤维蛋白原的百分比，这是对植入生物材料的许多不良反应的关键因素。事实上，使用动物植入模型，我们发现PDMS-PCL混合材料引发的炎症反应明显弱于聚氯乙烯（底物对照）。这些实验的结果表明，在聚合物共混物中使用PDMS-PCL添加剂（2.4%）是改善基底表面性能和改善生物材料生物相容性的有用手段。
Implantable biomaterials often trigger a variety of adverse responses. Because polydimethyl siloxane surfaces have good hemo- and bio-compatibility, it is generally believed that surface biocompatibility may be improved by modifying biomaterial surfaces with silicone-like properties. For this, we developed a series of polycaprolactone–polydimethylsiloxane–polycaprolactone (PDMS–PCL) copolymers. By mixing the substrate material—polyvinyl chloride—with low concentrations (1.2 and 2.4%) of the PDMS–PCL copolymer, we generated materials with silicone-like surface properties as reflected by increased surface silicon content and surface contact angles. We assessed the biocompatibility of these surfaces in vitro and found that the addition of PDMS–PCL significantly reduced the percentages of surface-‘denatured’ fibrinogen, a critical element of genesis of many adverse responses to implanted biomaterials. Indeed, using an animal implantation model, we find that PDMS–PCL-blended materials triggered significantly weaker inflammatory responses than did polyvinyl chloride, the substrate control. The results from these experiments suggest that the use of PDMS–PCL additives (2.4%) in polymer blends is a useful means of camouflaging the substrate surface properties and improving the biocompatibility of biomaterials.