Evidence of a Role for Fibrocyte and Keratinocyte-like Cells in the Formation of Hypertrophic Scars
Evidence of a Role for Fibrocyte and Keratinocyte-like Cells in the Formation of Hypertrophic Scars
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DOI：
10.1097/bcr.0b013e318254d1f9
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发表时间：
2013-03-01
影响因子：
1.4
通讯作者：
Ghahary, Aziz
中科院分区：
文献类型：
--
作者：
Curran, Terry-Ann;Ghahary, Aziz
烧伤每年影响数百万人，皮肤纤维化是受害者的常见并发症。这种缺陷具有功能和美容后果，许多研究小组已经将其作为工作的重点，以了解其发展的机制。虽然在伤口愈合过程中取得了重大进展，但所涉及的事件的复杂性使得很难提出一种单一的策略来预防这种破坏性的纤维化状况。炎症被认为是一个诱发因素，尽管这个阶段是伤口愈合过程的一个必要方面。由浸润的免疫细胞驱动的炎症在烧伤后几分钟开始，并且是伤口愈合早期阶段的普遍阶段。伴随着炎症浸润，有证据表明，骨髓来源的细胞亚群也存在。这些群体包括纤维细胞和角质形成细胞样细胞，CD14（+）单核细胞的衍生物，外周血单核细胞浸润的组分。有证据表明，这些细胞有助于伤口部位的再生和修复，但有趣的是，也有报道称，这些细胞可能具有不良影响，并可能有助于真皮纤维化的发展。在这篇文章中，作者介绍了这些细胞从骨髓干细胞的起源和转分化，指导这种转分化的环境，以及支持其在纤维化中作用的证据，以及控制其纤维化作用的治疗方法的潜在途径。（J Burn Care Res 2013; 34：227 - 231）
Burn injuries affect millions of people every year, and dermal fibrosis is a common complication for the victims. This disfigurement has functional and cosmetic consequences and many research groups have made it the focus of their work to understand the mechanisms that underlie its development. Although significant progress has been made in wound-healing processes, the complexity of events involved makes it very difficult to come up with a single strategy to prevent this devastating fibrotic condition. Inflammation is considered one predisposing factor, although this phase is a necessary aspect of the wound-healing process. Inflammation, driven by infiltrated immune cells, begins minutes after the burn injury and is the prevalent phase of wound healing in the early stages. Accompanying the inflammatory infiltrate, there is evidence that subpopulations of bone marrow-derived cells are also present. These populations include fibrocytes and keratinocyte-like cells, derivatives of CD14(+) monocytes, a component of the peripheral blood mononuclear cell infiltrate. There is evidence that these cells contribute to regeneration and repair of the wound site, but it is interesting to note that there are also reports that these cells can have adverse effects and may contribute to the development of dermal fibrosis. In this article, the authors present a review of the origin and transdifferentiation of these cells from bone marrow stem cells, the environments that direct this transdifferentiation, and evidence to support their role in fibrosis, as well as potential avenues for therapeutics to control their fibrotic effects. (J Burn Care Res 2013;34:227-231)