Mutagen Formation Potential of Composite Samples Prepared by Biodegradation of Agricultural Chemicals
Mutagen Formation Potential of Composite Samples Prepared by Biodegradation of Agricultural Chemicals
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农用化学品生物降解制备的复合样品的诱变剂形成潜力
DOI：
10.2965/jwet.2008.19
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发表时间：
2008
影响因子：
--
通讯作者：
A. Ohki
中科院分区：
文献类型：
--
作者：
M. Kishida;H. Takanashi;H. Kofune;T. Nakajima;A. Ohki
制备了有机磷、有机氯、农药等18种农药的10 mg-AC/L水溶液，进行了生物降解试验。通过试验获得的样品被认为含有各种分解产物，下文称为复合样品。测定了复合样品的致突变性和致突变物形成潜力（MFP），试验结果表明，在本研究中测试的AC不产生致突变物作为进行生物降解试验的结果。然而，18个样本中有12个表现出统计学显著的MFP。所有的12个AC，除了亚胺三乙酸，是芳香族化合物。对据报告具有致突变性的福美双和敌敌畏的比活度进行了测量，结果显示，mg和190净转速/ mg，分别。与这些值相比，由Ferimzone，pyridiphenthion，bentazone，bensultap和敌草胺获得的复合样品的MFP更大。因此，有人认为，一些AC，虽然他们是非诱变性化合物，当他们在水环境中的生物降解，可以形成强诱变剂，分解产物随后侵入原水供水，然后在净化厂氯化水。
Ten mg-AC/L aqueous solutions of 18 kinds of agricultural chemicals (ACs), such as organophosphorus, organochlorine and amidic chemicals, were prepared and underwent the biodegradation test. The samples attained through the test were considered to contain various decomposition products, hereafter referred to as composite samples. Mutagenicity and mutagen formation potential (MFP) were measured for the composite samples, and the test results revealed that the ACs tested in the present study do not produce mutagens as a result of undergoing the biodegradation test. However, 12 out of 18 samples manifested statistically significant MFP. All of the 12 ACs, except for iminoctadine-triacetate, were aromatic compounds. Specific activities for thiram and DDVP, which were reported to be mutagenic, were measured, showing 320 net rev./mg and 190 net rev./mg respectively. Compared with these values, MFP of the composite samples attained from ferimzone, pyridiphenthion, bentazone, bensultap, and napropamide were greater. Accordingly, it was suggested that some ACs, though they were non-mutagenic compounds, could form strong mutagens when they were biodegraded in a water environment, and the decomposition products subsequently intruded into the raw water for water supply, and the water was then chlorinated at a purification plant.