GENETIC STUDIES OF THE RELATIONSHIP OF TUMOUR-HOST CELLS - EFFECT OF TUMOUR CELLS KILLED BY X-RAYS UPON THE GROWTH OF ADMIXED VIABLE CELLS
GENETIC STUDIES OF THE RELATIONSHIP OF TUMOUR-HOST CELLS - EFFECT OF TUMOUR CELLS KILLED BY X-RAYS UPON THE GROWTH OF ADMIXED VIABLE CELLS
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DOI：
10.1038/1781391a0
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发表时间：
1956-01-01
期刊：
影响因子：
64.8
通讯作者：
REVESZ, L
中科院分区：
文献类型：
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作者：
REVESZ, L
用亚致死X射线剂量照射的肿瘤可以被示意性地认为含有两种肿瘤细胞，它们的预期基因型生殖潜力不同。其中一部分已受到不可逆转的损害，以致失去了继续繁殖的能力。这些细胞可能立即死亡，也可能在多次细胞分裂后死亡1• 细胞群的另一部分由未受损或以可逆方式受损的细胞组成，并且仍然能够不受限制地连续繁殖。这两个部分的相对比例可能与X射线剂量、细胞固有的敏感性以及照射期间的各种环境条件有关。对于致命受损群体可能直接或通过宿主生物体对存活部分的持续增殖产生的潜在影响知之甚少。可以想象，垂死的细胞可能会以多种方式刺激幸存者的生长。但同样可能的是，它们通过有毒产物或在宿主体内引起强烈的局部炎症反应来抑制它们。通过以不同比例混合不可逆受损和存活的小鼠肿瘤细胞，通过实验解决了这个问题。两妈。在肿瘤类型中使用。第一组包括以下肿瘤：在高度近交系的小鼠或通过两个近交系杂交产生的 F 1 杂种中，该病毒自发出现或由致癌物诱导。这些肿瘤在单代转移到原始基因型的小鼠中后使用。另一类以·为代表。艾利希腹水肿瘤起源于小鼠
TUMOURS irradiated with isublethal X-ray doses can be schematically considered as containing two kinds of tumour cells, differing in their prospective genotype reproductive potentialities. One fraction has been damaged irreversibly so as to lose the ability for continued reproduction. These cells may die immediately or after a number of cell divisions1• Another part of the cell population is composed of cells undamaged or damaged in a reversible way, and still capable of multiplying serially without restraint. The relative proportion of these two fractions is probably related to the X-ray dose, the inherent sensitivity of the cells and to various environmental conditions during irradiation. Very little is known about the potential influence that the lethally damaged population may exert on the continued proliferation of the surviving fraction, either directly or through the host organism. It is conceivable that the dying cells may stimulate the growth of tho survivors in a variety of ways; but it is equally possible that they inhibit them by toxic products or as a result of the intense local inflammatory reaction they induce in the host. The problem was approached experimentally by mixing irreversibly damaged and viable mouse tumour cells in various proportions. Two ma. in tumour types were used. The first group includes neoplasms that a. rose spontaneously or have been induced by carcinogens in mice of highly inbred strains or in F 1 hybrids produced by crossing two inbred strains. These tumours were used after a single generation of transfer into mice of the original genotype. Another category is represented by·. the Ehrlich ascites tumour that originated in a mouse of