Outcomes after radiotherapy for squamous cell carcinoma of the eyelid
Outcomes after radiotherapy for squamous cell carcinoma of the eyelid
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DOI：
10.1002/cncr.23143
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发表时间：
2008-01-01
期刊：
影响因子：
6.2
通讯作者：
Esmaeli, Bita
中科院分区：
文献类型：
--
作者：
Petsuksiri, Janjira;Frank, Steven J.;Esmaeli, Bita
背景资料。眼睑鳞状细胞癌(SCC)是一种罕见的有转移潜能的恶性肿瘤。方法回顾1950-2005年间I所收治的所有眼睑鳞状细胞癌患者接受放射治疗的临床资料。分析患者的临床特征、病理特征、放射治疗技术和治疗结果。生存率采用Kaplan-Meier法，影响生存率的因素采用对数等级检验。结果：39例42眼睑鳞状细胞癌患者接受了放射治疗。其中32例为直接放射治疗，10例为局部广泛切除术后放射治疗。存活的患者接受了中位时间为76个月的随访。所有患者的5年疾病特异性存活率和总存活率分别为86%和71%。5年后，所有肿瘤的局部、区域和远程疾病控制率分别为88%、95%和97%。在接受确定性治疗的肿瘤和接受术后放疗的肿瘤之间，5年的局部、区域和远程控制率没有显著差异。无3级或4级并发症。结论：眼睑鳞状细胞癌的初次放射治疗提供了良好的局部控制性和合理的并发症发生率，应考虑在选定的患者中作为手术的替代方案。
BACKGROUND. Squamous cell carcinoma (SCC) of the eyelid is a rare malignancy with metastatic potential. In the current study, the Outcomes of patients with SCC of the eyelid were evaluated after definitive and postoperative radiation therapy.METHODS. The medical records of all patients treated with radiotherapy for SCC of the eyelid at I institution between 1950 and 2005 were reviewed. Patient records were analyzed for clinical characteristics, pathologic features, radiation techniques, and outcomes. Survival rates were calculated using the Kaplan-Meier method; factors affecting survival were assessed using the log-rank test.RESULTS. During the study period, 39 patients with 42 eyelid SCCs were treated with radiotherapy. Thirty-two tumors were treated with primary radiotherapy and 10 were treated with postoperative radiotherapy after wide local excision. Surviving patients were followed for a median of 76 months. The 5-year disease-specific and overall survival rates for all patients were 86% and 71%, respectively. At 5 years, local, regional, and distant disease control rates for all tumors were 88%, 95%, and 97%, respectively. There were no significant differences in the 5-year local, regional, and distant control rates between tumors treated with definitive and those treated with postoperative radiotherapy. There were no grade 3 or 4 complications.CONCLUSIONS. Primary radiotherapy for SCC of the eyelid provides excellent locoregional control with reasonable complication rates and should be considered an alternative to surgery in selected patients.