Research progress of bacterial quorum sensing receptors: Classification, structure, function and characteristics
Research progress of bacterial quorum sensing receptors: Classification, structure, function and characteristics
复制标题
细菌群体感应受体的研究进展：分类、结构、功能和特点。
DOI：
10.1016/j.scitotenv.2020.143031
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发表时间：
2021
影响因子：
9.8
通讯作者：
Yang Wang
中科院分区：
文献类型：
--
作者：
Li Yi;Xiao Dong;Daniel Grenier;Kaicheng Wang;Yang Wang
微生物群落是自然生态系统的重要组成部分，群体感应系统是微生物群落与周围环境联系的重要通讯工具。群体感应是一种细胞间通讯的过程，依赖于细胞外信号分子的产生、释放和检测，这些信号分子被称为自诱导物。细菌中的群体感应系统由两个主要成分组成：受体蛋白和自诱导物。自诱导物与其受体的结合激活靶基因，然后在细菌中执行相应的功能。在自然环境中，不同的细菌物种具有结构和功能不同的群体感应受体。到目前为止，许多细菌群体感应受体已被鉴定，一些受体的结构和功能已被确定。关于群体感应和群体感应受体的综述很多，但以受体为核心描述不同环境下各种类型的群体感应的综述却不多。因此，我们总结了参与种内和种间细胞间通讯的定义明确的群体感应受体，并描述了不同类型的群体感应的典型受体的结构，功能和特征。对群体感应受体的系统认识将有助于研究者进一步探索群体感应系统的信号传导机制和调控机制，为阐明群体感应在自然生态系统中的作用和功能提供帮助，进而为发现或合成阻断群体感应的新型靶向药物提供理论依据。
The microbial community is an important part of the natural ecosystem, and the quorum sensing system is a momentous communication tool for the microbial community to connect to the surrounding environment. Quorum sensing is a process of cell-cell communication that relies on the production, release, and detection of extracellular signaling molecules, which are called autoinducers. Quorum sensing systems in bacteria consist of two main components: a receptor protein and an autoinducer. The binding of autoinducer to its receptor activates the target gene, which then performs the corresponding function in bacteria. In a natural environment, different bacterial species possess quorum sensing receptors that are structurally and functionally different. So far, many bacterial quorum sensing receptors have been identified and the structure and function of some receptors have been characterized. There are many reviews about quorum sensing and quorum sensing receptors, but there are few reviews that describe various types of quorum sensing in different environments with receptors as the core. Therefore, we summarize the well-defined quorum sensing receptors involved in intra-species and inter-species cell-cell communication, and describe the structure, function, and characteristics of typical receptors for different types of quorum sensing. A systematic understanding of quorum sensing receptors will help researchers to further explore the signaling mechanism and regulation mechanism of quorum sensing system, provide help to clarify the role and function of quorum sensing in natural ecosystems, then provide theoretical basis for the discovery or synthesis of new targeted drugs that block quorum sensing.