Occupational exposure to chlorophenol and the risk of nasal and nasopharyngeal cancers among US men aged 30 to 60
Occupational exposure to chlorophenol and the risk of nasal and nasopharyngeal cancers among US men aged 30 to 60
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DOI：
10.1002/(sici)1097-0274(200005)37:5
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发表时间：
2000-05-01
影响因子：
3.5
通讯作者：
Brann, EA
中科院分区：
文献类型：
--
作者：
Mirabelli, MC;Hoppin, JA;Brann, EA
方法对43例鼻癌患者、92例鼻咽癌患者和1909例对照人群的职业信息进行访谈，采用精确条件Logistic回归方法分析氯苯酚暴露与鼻咽癌和鼻咽癌发病的关系。中高强度氯酚接触者(n(暴露者)=18，OR=1.94，95%CI=1.03~3.50)和高强度暴露者(n(暴露者)=3，OR=9.07，95%CI=1.41~42.9)患鼻咽癌的危险性增加。控制估计的甲醛和木尘暴露并没有改变这些结果，因为估计的氯酚暴露大部分是机械师。结论这些发现支持职业接触氯酚是鼻腔和鼻咽部取消的危险因素的假设；尽管与机械加工相关的暴露的作用值得进一步评估。上午好。J.Ind.地中海医院。2000年，37：532-541。(C)2000 Wiley-Liss，Inc.
Background Elevated rates of nasal and nasopharyngeal cancers have been associated with wood-related occupational exposures, including chlorophenols, formaldehyde, and wood dust.Methods Occupational information was obtained from 43 nasal carcinoma cases, 92 nasopharyngeal carcinoma cases, and 1909 controls, by interview Exact conditional logistic regression was used to evaluate the association of these cancers with chlorophenol exposure, estimated from a review of verbatim responses.Results Both nasal and nasopharyngeal cancers were significantly associated with estimated duration of chlorophenol exposure. For nasopharyngeal cancer elevated risk was observed among those who held jobs assigned medium or high intensity chlorophenol exposure (n(exposed)=18, OR=1.94, 95% Cl=1.03-3.50) and among those with 10+ years in jobs assigned high intensity with high certainty (n(exposed) = 3, OR = 9.07, 95% CI = 1.41-42.9). Controlling for estimated formaldehyde and wood dust exposure did not alter these findings, as much of the estimated chlorophenol exposure was among machinists.Conclusions These findings support the hypothesis that occupational exposure to chlorophenol is a risk factor for nasal and nasopharyngeal cancel; although the role of machining-related exposures warrants further assessment. Am. J. Ind. Med. 37:532-541, 2000. (C) 2000 Wiley-Liss, Inc.