POHaD: why we should study future fathers.
POHaD: why we should study future fathers.
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DOI：
10.1093/eep/dvy007
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发表时间：
2018-04
影响因子：
3.8
通讯作者：
Soubry A
中科院分区：
文献类型：
--
作者：
Soubry A
“健康和疾病的发育起源”（DOHaD）这一日益增长的领域通常反映了母亲对儿童的环境影响。产妇的生活方式、饮食和怀孕前和怀孕期间的其他环境暴露的重要性已得到公认。然而，很少有流行病学设计探讨父亲环境对后代健康的潜在影响。这是令人惊讶的，因为许多动物模型已经提供了证据，证明父系环境通过雄性生殖系在受孕前暴露的非遗传遗传中发挥作用。最近的人类研究结果表明，精子细胞的表观基因组确实会受到父亲暴露的影响。表观遗传精子机制的缺陷可能会导致持续的修改，影响男性生育力或后代的健康状况。我们在2017年8月28日至30日在苏黎世举行的LATSIS研讨会“跨代表观遗传遗传：对生物学和社会的影响”上解决了这个问题，并在这里提供了为什么应该研究年轻男性环境和生活方式相关暴露的重要论据。父亲的健康和疾病的起源（POHaD）范式的引入，强调需要更多的研究父亲的作用，从他的环境中获得的环境信息传递给他的后代。更好地了解疾病的前概念起源，通过父亲的染色体组将是跨代表观遗传学领域的信息，并最终将有助于指导和指导未来的公共卫生政策。
The growing field of ‘Developmental Origin of Health and Disease’ (DOHaD) generally reflects environmental influences from mother to child. The importance of maternal lifestyle, diet and other environmental exposures before and during gestation period is well recognized. However, few epidemiological designs explore potential influences from the paternal environment on offspring health. This is surprising given that numerous animal models have provided evidence that the paternal environment plays a role in a non-genetic inheritance of pre-conceptional exposures through the male germ line. Recent findings in humans suggest that the epigenome of sperm cells can indeed be affected by paternal exposures. Defects in epigenetic sperm mechanisms may result in persistent modifications, affecting male fertility or offspring health status. We addressed this issue at the LATSIS Symposium ‘Transgenerational Epigenetic Inheritance: Impact for Biology and Society’, in Zürich, 28–30 August 2017, and here provide important arguments why environmental and lifestyle-related exposures in young men should be studied. The Paternal Origins of Health and Disease (POHaD) paradigm was introduced to stress the need for more research on the role of the father in the transmission of acquired environmental messages from his environment to his offspring. A better understanding of pre-conceptional origins of disease through the paternal exposome will be informative to the field of transgenerational epigenetics and will ultimately help instruct and guide public health policies in the future.