Cyclic AMP mediates the negative regulation of Y-organ ecdysteroid production.
Cyclic AMP mediates the negative regulation of Y-organ ecdysteroid production.
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环磷酸腺苷介导 Y 器官蜕皮类固醇产生的负调节。
DOI：
10.1016/0303-7207(85)90106-6
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发表时间：
1985
影响因子：
4.1
通讯作者：
Spaziani,E
中科院分区：
文献类型：
--
作者：
Mattson,MP;Spaziani,E
假定的神经肽，蜕皮抑制激素（MIH），调节甲壳动物的生长周期性抑制分泌蜕皮激素从外周腺（Y-器官）。环磷酸腺苷（cAMP）在MIH行动中的介导作用进行了评估与分离的Y-器官的螃蟹，癌症antennarius。MIH活性眼柄提取物抑制蜕皮激素的分泌，但增加cAMP水平的剂量依赖性在24小时的孵育。cAMP升高先于蜕皮激素抑制的发作。二丁酰cAMP，腺苷酸环化酶（毛喉素，choleragen）的激活剂，磷酸二酯酶（IBMX）的抑制剂，但不是AMP或cGMP，模仿MIH的抑制作用。
The putative neuropeptide, molt-inhibiting hormone (MIH), regulates crustacean growth by periodically suppressing the secretion of ecdysteriod molting hormone from peripheral glands (Y-organs). A mediating role for cyclic AMP (cAMP) in MIH action was evaluated with isolated Y-organs of the crab,Cancer antennarius. MIH activity in eyestalk extracts inhibited ecdysteroid secretion but increased cAMP levels dose-dependently in 24-h incubations. The cAMP rise preceded the onset of ecdysteroid suppression. Dibutyryl cAMP, activators of adenylate cyclase (forskolin, choleragen), and an inhibitor of phosphodiesterase (IBMX), but not AMP or cGMP, mimicked the inhibitory action of MIH.