Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration.
Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration.
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DOI：
10.1038/cr.2014.135
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发表时间：
2015-01
期刊：
影响因子：
44.1
通讯作者：
Yu L
中科院分区：
文献类型：
--
作者：
Ma L;Li Y;Peng J;Wu D;Zhao X;Cui Y;Chen L;Yan X;Du Y;Yu L
细胞之间通过分泌和释放蛋白质和囊泡进行交流。许多细胞可以迁移。在这项研究中，我们报告了偏头痛和迁移小体的发现，偏头痛是一种细胞迁移依赖的释放细胞内容物的机制，而迁移小体是介导偏头痛的囊泡结构。当迁移的细胞移动时，它们会在身后留下被称为回缩纤维的长管束。大小泡生长在回缩纤维的顶端和交叉点上，其中包含许多较小的小泡。这些连接小泡和主细胞体的纤维最终破裂，小泡被释放到细胞外空间或直接被周围细胞吸收。由于这些囊泡的形成依赖于迁移，因此我们将其命名为“迁移体”。我们还发现，胞浆内容物可以运输到迁移体，并通过迁移体从细胞中释放出来。我们将这种依赖于迁移的释放机制命名为偏头痛。
Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration-dependent, we named them “migrasomes”. We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration-dependent release mechanism “migracytosis”.