Xenotransplantation--the future of corneal transplantation?
Xenotransplantation--the future of corneal transplantation?
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DOI：
10.1097/ico.0b013e3181f237ef
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发表时间：
2011-04
期刊：
影响因子：
2.8
通讯作者：
Cooper DK
中科院分区：
文献类型：
--
作者：
Hara H;Cooper DK
虽然角膜移植在美国和发达国家的某些其他地区很容易获得，但全世界对人类供体角膜的需求远远超过供应。目前，人们对使用其他物种，特别是猪的角膜移植到人类（异种移植）的可能性重新产生了兴趣。人和猪角膜的生物力学特性相似。在异种角膜移植动物模型中的研究已经证明了在异种移植排斥反应中起作用的体液和细胞免疫应答。从野生型角膜（即，转基因猪转化为非人灵长类动物的研究已经取得了令人惊讶的进展，令人鼓舞。猪的遗传操作的最新进展已经导致剩余的免疫障碍将被克服的前景。有充分的理由乐观地认为，角膜xenoTx将在未来几年内成为临床现实。
Although corneal transplantation is readily available in the USA and certain other regions of the developed world, the need for human donor corneas worldwide far exceeds supply. There is currently renewed interest in the possibility of using corneas from other species, especially pigs, for transplantation into humans (xenotransplantation). The biomechanical properties of human and pig corneas are similar. Studies in animal models of corneal xenotransplantation have documented both humoral and cellular immune responses that play roles in xenograft rejection. The results obtained from the Tx of corneas from wild-type (i.e., genetically-unmodified) pigs into nonhuman primates have been surprisingly good and encouraging. Recent progress in the genetic manipulation of pigs has led to the prospect that the remaining immunological barriers will be overcome. There is every reason for optimism that corneal xenoTx will become a clinical reality within the next few years.