TOTAL PLASMA SEROTONIN 5-HYDROXYINDOLEACETIC ACID AND P-HYDROXY-M-METHOXYMANDELIC ACID EXCRETION IN NORMAL AND MIGRAINOUS SUBJECTS - WITH AN APPENDIX ON STATISTICAL ANALYSIS
TOTAL PLASMA SEROTONIN 5-HYDROXYINDOLEACETIC ACID AND P-HYDROXY-M-METHOXYMANDELIC ACID EXCRETION IN NORMAL AND MIGRAINOUS SUBJECTS - WITH AN APPENDIX ON STATISTICAL ANALYSIS
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DOI：
10.1093/brain/88.5.997
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发表时间：
1965-01-01
期刊：
影响因子：
14.5
通讯作者：
JOFFE, AD
中科院分区：
文献类型：
--
作者：
CURRAN, DA;HINTERBERGER, H;JOFFE, AD
在偏头痛发作的不同阶段，颅血管收缩和扩张。Schmid、Waltz和Freund（1956）指出，快速输注大量5-羟色胺可引起血管收缩，而缓慢输注少量5-羟色胺则可引起血管舒张。霍兰德、迈克尔逊和威尔金斯（1957年）证明，人体受试者的总循环效应也随注射的5-羟色胺量而变化，低剂量（小于0-75 mg）时为降压药。高剂量（0-75-2毫克）降压。在去神经支配的狗前肢中，大动脉和静脉被5-羟色胺收缩，而小动脉扩张（Hurwitz，坎贝尔，Gordon和Haddy，1961）。
The cranial vessels constrict and dilate in various phases of the migraine attack. Schmid, Waltz and Freund (1956) showed that vasoconstriction could be produced by the rapid infusion of a large amount of serotonin, but that vasodilatation resulted from the slow infusion of small quantities. Hollander, Michelson and Wilkins (1957) demonstrated that the total circulatory effect in human subjects also varies with the amount of serotonin injected, being depressor with low doses (less than 0-75 mg.) and pressor with high doses (0-75-2 mg.). In the denervated dog fore-limb, large arteries and veins are constricted by serotonin whereas arterioles are dilated (Hurwitz, Campbell, Gordon and Haddy, 1961).