Chronic D-amphetamine induces sexually dimorphic effects on locomotion, recognition memory, and brain monoamines
Chronic D-amphetamine induces sexually dimorphic effects on locomotion, recognition memory, and brain monoamines
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DOI：
10.1016/s0091-3057(03)00017-0
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发表时间：
2003-03-01
影响因子：
3.6
通讯作者：
Luine, VN
中科院分区：
文献类型：
--
作者：
Bisagno, V;Ferguson, D;Luine, VN
虽然急性和慢性 D-安非他明 (AMPH) 治疗使雌性大鼠的运动活动得分高于雄性大鼠，但人们对 AMPH 引起的认知性别差异知之甚少。本研究的目的是（1）调查长期 AMPH 治疗后的戒断期期间，两项记忆任务、物体识别（OR）和物体放置（OP）的表现是否发生改变，以及（2）确定戒断期后的 AMPH 激发剂量是否会放大先前报道的运动活动和神经化学方面的性别差异。 Sprague-Dawley 雄性和雌性成年大鼠接受慢性 AMPH 治疗（10 次注射，每隔一天注射一次；雄性：3 mg/kg，雌性 2.6 mg/kg）。对运动活动进行量化（急性、慢性和 16 天停药期后）。在停药第 16 天接受 AMPH 激发剂量后，评估大脑区域的神经递质水平。在停药期间，接受 AMPH 治疗的雄性动物的 OR（延迟 2 小时和 4 小时）受到损害，但 OP 没有表现出任何损害； AMPH 雌性也表现出 OR 受损（仅延迟 4 小时）。 AMPH 雌性在急性和慢性治疗后表现出更多的运动能力，但在攻击剂量后，AMPH 引起的过度活跃对于雌性和雄性来说是相当的。停药期后接受挑战剂量的 AMPH 后，发现纹状体中多巴胺能和血清素能神经传递的性别差异。 AMPH 在单胺能途径中引起的这些性别差异可能与参与运动和 OR 记忆的行为成分的性别差异有关。 (C) 2003 Elsevier Science Inc. 保留所有权利。
While acute and chronic D-amphetamine (AMPH) treatments produce greater scores for locomotor activity in female rats in comparison with male rats, little is known about AMPH-induced gender differences on cognition. The objectives of the present study were to (1) investigate during a withdrawal period following chronic AMPH treatment whether performance of two memory tasks, object recognition (OR) and object placement (OP) are altered, and (2) determine if an AMPH challenge dose after a withdrawal period amplifies previously reported gender differences in locomotor activity and neurochemistry. Sprague-Dawley male and female adult rats were included in a chronic AMPH treatment (10 injections, I every other day; males: 3 mg/kg, females 2.6 mg/kg). Locomotor activity was quantified (acute, chronic, and after a 16-day withdrawal period). Neurotransmitter levels in brain areas were evaluated after an AMPH challenge dose on the 16th withdrawal day. During the withdrawal period, OR (2- and 4-h delays) was impaired in AMPH-treated males but they did not show any impairment in OP; AMPH females also showed impairments in OR (only 4-h delay). AMPH females showed more locomotion after acute and chronic treatment but AMPH-induced hyperactivity was comparable for females and males after a challenge dose. Following a challenge dose of AMPH after a withdrawal period, gender differences in dopaminergic and serotonergic neurotransmission in the striatum were found. These gender differences elicited by AMPH in monoaminergic pathways may be related to sex differences on behavioral components involved in locomotion and OR memory. (C) 2003 Elsevier Science Inc. All rights reserved.