Tumor microenvironment and radioresistance.
Tumor microenvironment and radioresistance.
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肿瘤微环境与放射抗性
DOI：
10.1038/s12276-021-00640-9
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发表时间：
2021-06
影响因子：
12.8
通讯作者：
Harada H
中科院分区：
文献类型：
--
作者：
Suwa T;Kobayashi M;Nam JM;Harada H
转移并非随机事件的结果，因为癌细胞只有在适宜的组织微环境中才能活跃地维持和增殖，进而形成转移灶。自英国的斯蒂芬·佩吉特博士基于植物种子只有在适宜的土壤中才能发芽生长这一类比提出癌症转移的“种子与土壤”假说以来，人们相当关注影响癌细胞生长的细胞外环境因素以及影响微环境的组织结构。恶性肿瘤组织不仅由癌细胞组成，还包含多种其他细胞，这些细胞负责炎症反应、血管形成、免疫反应以及对肿瘤组织结构的支撑，形成了一个复杂的细胞群体。众所周知，肿瘤组织中每个细胞所获得的氧气和营养物质的量因与肿瘤血管的距离不同而有所差异。在此，我们对肿瘤微环境和肿瘤组织的特征进行综述，这两者都会影响癌细胞的恶性表型和放射抗性，重点关注以下关键词：肿瘤组织中氧气和营养微环境的多样性、炎症、免疫以及肿瘤血管系统。
需要对所有癌症类型的不同肿瘤微环境进行广泛研究，以便为新的治疗策略提供依据。癌症要发生转移，周围肿瘤微环境的条件必须恰到好处；这种“种子与土壤”假说促使近期对影响癌症行为的细胞外因素展开研究。日本京都大学的原田浩及其同事综述了目前对肿瘤微环境及其对放射抗性影响的认识。每个肿瘤都呈现出独特的微环境，其中包含多种参与复杂相互作用的细胞类型，这些细胞群体的组成会影响炎症、血管形成和免疫反应。在急性和慢性时间尺度上，到达癌细胞的氧气和营养物质水平在肿瘤区域内差异很大，动态地影响着癌细胞的特性。多种细胞群体的存在以及缺氧的肿瘤区域最终似乎会降低放疗的成功率。
Metastasis is not the result of a random event, as cancer cells can sustain and proliferate actively only in a suitable tissue microenvironment and then form metastases. Since Dr. Stephen Paget in the United Kingdom proposed the seed and soil hypothesis of cancer metastasis based on the analogy that plant seeds germinate and grow only in appropriate soil, considerable attention has focused on both extracellular environmental factors that affect the growth of cancer cells and the tissue structure that influences the microenvironment. Malignant tumor tissues consist of not only cancer cells but also a wide variety of other cells responsible for the inflammatory response, formation of blood vessels, immune response, and support of the tumor tissue architecture, forming a complex cellular society. It is also known that the amounts of oxygen and nutrients supplied to each cell differ depending on the distance from tumor blood vessels in tumor tissue. Here, we provide an overview of the tumor microenvironment and characteristics of tumor tissues, both of which affect the malignant phenotypes and radioresistance of cancer cells, focusing on the following keywords: diversity of oxygen and nutrient microenvironment in tumor tissue, inflammation, immunity, and tumor vasculature. Extensive research into diverse tumor microenvironments in all cancer types is needed to inform novel therapeutic strategies. For cancer to metastasize, the conditions of the surrounding tumor microenvironment must be just right; this ‘seed and soil’ hypothesis has prompted recent research into extracellular factors influencing cancer behavior. Hiroshi Harada at Kyoto University in Japan and co-workers reviewed current understanding of tumor microenvironments and their influence on radiation resistance. Every tumor displays a unique microenvironment comprising multiple cell types involved in complex crosstalk, and the composition of these cellular communities influences inflammation, blood vessel formation and immune responses. On acute and chronic timescales, the levels of oxygen and nutrients reaching cancer cells varies widely across tumor regions, dynamically influencing character of cancer cells. The presence of diverse cellular society and oxygen-poor tumor regions eventually appear to reduce radiotherapy success.
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DOI：
10.1158/1078-0432.ccr-16-3122
发表时间：
2017-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Brown JM;Recht L;Strober S
通讯作者：
Strober S
影响因子：
11.2
作者：
Barsoum, Ivraym B.;Smallwood, Chelsea A.;Graham, Charles H.
通讯作者：
Graham, Charles H.
影响因子：
2.6
作者：
BROWN, JM
通讯作者：
BROWN, JM
影响因子：
4
作者：
Dehnel, Nathalie;Moral, Javier;Bruenet, Bernhard
通讯作者：
Bruenet, Bernhard
DOI：
10.1016/j.ijrobp.2004.03.025
发表时间：
2004-10-01
影响因子：
7
作者：
Ishikawa, H;Sakurai, H;Nakano, T
通讯作者：
Nakano, T