Emergence of azole-resistant Candida parapsilosis causing bloodstream infection: results from laboratory-based sentinel surveillance in South Africa
Emergence of azole-resistant Candida parapsilosis causing bloodstream infection: results from laboratory-based sentinel surveillance in South Africa
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DOI：
10.1093/jac/dkw091
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发表时间：
2016-07-01
影响因子：
5.2
通讯作者：
Zietsman, Inge L.
中科院分区：
文献类型：
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作者：
Govender, Nelesh P.;Patel, Jaymati;Zietsman, Inge L.
目的：比较南非公立和私立医院念珠菌的种类分布和对真菌的敏感性。方法：从2009年2月到2010年8月，在南非11家公立医院和85家私立医院进行了基于实验室的念珠菌血症监测。病例被定义为从血培养中分离出念珠菌而住进哨兵医院的任何年龄的患者。在一个参考实验室中鉴定了可存活的菌株并进行了抗真菌敏感性测试。从实验室记录中提取人口学和有限的临床数据。结果：共检出念珠菌血症2172例。在有可用数据的患者中，几乎三分之二是危重患者(719/1138，63%)。在多变量分析中，新生儿[调整后OR(AOR)，2.2；95%CI，1.5~3.1；P
Objectives: To compare Candida species distribution and antifungal susceptibility at South African public-and private-sector hospitals.Methods: From February 2009 through to August 2010, laboratory-based surveillance for candidaemia was undertaken at 11 public-sector hospitals and >85 private-sector hospitals across South Africa. A case was defined as a patient of any age admitted to a sentinel hospital with isolation of Candida species from blood culture. Viable isolates were identified and tested for antifungal susceptibility at a reference laboratory. Demographic and limited clinical data were abstracted from laboratory records.Results: In total, 2172 cases of candidaemia were detected. Among patients with available data, almost two-thirds were critically ill (719/1138, 63%). On multivariable analysis, neonates [adjusted OR (aOR), 2.2; 95% CI, 1.5-3.1; P