Developing Cellular Therapies for Stroke.
Developing Cellular Therapies for Stroke.
复制标题
开发中风的细胞疗法。
DOI：
10.1161/strokeaha.115.007149
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发表时间：
2015-07
期刊：
影响因子：
8.3
通讯作者：
Savitz SI
中科院分区：
文献类型：
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作者：
Savitz SI
中风导致活跃的炎症反应，涉及外周和中枢机制。5来自外周器官的炎症细胞和细胞因子循环到大脑并导致二次损伤。在脑内，一系列涉及神经血管单位的精心安排的事件加剧了损伤，并威胁到梗死周边的存活神经元。然而，神经炎症的某些方面对大脑有益，对恢复过程至关重要。一系列细胞疗法已被证明可以改变中风后炎症反应的不同方面，从而使促炎有害途径下调，抗炎途径上调。小胶质细胞/巨噬细胞似乎是神经炎症中受细胞疗法调节的主要细胞类型之一。6–8
Stroke leads to a brisk inflammatory response involving both peripheral and central mechanisms. 5 Inflammatory cells and cytokines from peripheral organs circulate to the brain and contribute to secondary injury. Within the brain, a series of orchestrated events involving the neurovascular unit exacerbate damage and threaten surviving neurons in the periphery of an infarct. However, some aspects of neuroinflammation are beneficial to the brain and are critical to recovery processes. 5 A range of cell therapies have been shown to modify different aspects of the inflammatory response after stroke in such a way that proinflammatory detrimental pathways are downregulated and anti-inflammatory pathways are upregulated. Microglia/macrophages seem to be one of the principal cell types in neuroinflammation that are modulated by cell therapies. 6–8