Pulsed arterial spin labeling parameter optimization for an elderly population
Pulsed arterial spin labeling parameter optimization for an elderly population
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DOI：
10.1002/jmri.20503
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发表时间：
2006-03-01
影响因子：
4.4
通讯作者：
Beaulieu, C
中科院分区：
文献类型：
--
作者：
Campbell, AM;Beaulieu, C
目的：优化老年人的脉冲动脉自旋标记（PASL）参数，以考虑随年龄增长大脑可能发生的灌注变化。材料与方法：健康青年（N = 14）。年龄范围21-27岁)和老年人（N = 12，年龄范围61-67岁）采用Q2TIPS （QUIPSS II薄层Tl周期性饱和）扫描，在1.5T时不同的反转时间（TI2）。计算脑灰质（GM）的差信号（Delta M）、传递时间（Delta t）和脑血流量（CBF）。结果：青年人各ti2s灌注加权信号差异大于老年人。AM的峰值出现在TI2，分别为青年组1300 msec和老年组1500 msec。定性地说，年轻人的血管内信号在TI2 = 1500 msec时最小，而老年人则需要更长的TI2 （1800 msec）来最小化该信号。老年人的传递时间延长约100 msec， CBF在文献值范围内。结论：对于老年人PASL脑灌注研究获取血管内信号最小、组织信号充足的灌注加权图像，较长的反转时间是有利的。
Purpose: To optimize pulsed arterial spin labeling (PASL) parameters for the elderly to take into account possible perfusion changes that occur in the brain with age.Materials and Methods: Healthy young (N = 14. age range = 21-27 years) and elderly (N = 12, age range 61-67 years) subjects were scanned using Q2TIPS (QUIPSS II with thin-slice Tl periodic saturation) with varying inversion times (TI2) at 1.5T. The difference signal (Delta M), transit time (delta t). and cerebral blood flow (CBF) were calculated in segmented gray matter (GM).Results:The young displayed more perfusion-weighted signal difference than the elderly at all TI2'S. The peak AM occurred at TI2 similar to 1300 msec and 1500 msec in the young and elderly groups, respectively. Qualitatively, intravascular signal was minimal in the younger group by TI2 = 1500 msec, whereas a longer TI2 of 1800 msec was needed to minimize this signal in the elderly. The transit time was similar to 100 msec longer in the elderly, and CBF was in the range of literature values.Conclusion: For acquiring perfusion-weighted images with minimal intravascular signal and adequate tissue signal for PASL studies of cerebral perfusion in the elderly, a longer Inversion time is advantageous.