SYLVIAN FISSURE ASYMMETRIES IN MONOZYGOTIC TWINS - A TEST OF LATERALITY IN SCHIZOPHRENIA
SYLVIAN FISSURE ASYMMETRIES IN MONOZYGOTIC TWINS - A TEST OF LATERALITY IN SCHIZOPHRENIA
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DOI：
10.1016/0006-3223(93)90053-g
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发表时间：
1993-12-15
影响因子：
10.6
通讯作者：
WEINBERGER, DR
中科院分区：
文献类型：
--
作者：
BARTLEY, AJ;JONES, DW;WEINBERGER, DR
为了处理先前的报告，即精神分裂症与正常大脑不对称性的丧失有关，并且它可能与控制大脑偏侧化的基因缺陷有关，我们测量了来自磁共振成像(MRI)的三维皮质渲染图，扫描了10对正常单卵(MZ)双胞胎(n=10对)和10对不和谐的精神分裂症(n=10对)MZ双胞胎的侧裂的长度和角度。我们在两组双胞胎中都证实了预期的侧裂长度和角度的正常不对称。我们还证实，长度不对称仅发生在颞平面区域。在不和谐双胞胎中，受影响和未受影响的双胞胎在不对称测量上没有差异，因此无法支持疾病本身和减少不对称之间的联系。此外，不协调双胞胎作为一个组与正常双胞胎作为一个组没有区别，因此未能证实基因与异常不对称有关的假说。讨论了方法学和患者样本变化的影响。
To address prior reports that schizophrenia is associated with loss of normal brain asymmetry and that it might be linked to a defect of a gene controlling cerebral lateralization, we measured on three-dimensional cortical renderings from magnetic resonance imaging (MRI) scans the lengths and angles of the sylvian fissures in 10 normal monozygotic (MZ) twin pairs (n=10 pairs) and in 10 MZ pairs discordant for schizophrenia (n=10 pairs). We confirmed in both sets of twins the expected normal asymmetries of length and angle of the sylvian fissure. We also confirmed that the length asymmetry occurs solely in the region of the planum temporale. In the discordant twins, affected and unaffected twins did not differ in asymmetry measures, thus failing to support an association between illness per se and diminished asymmetry. Moreover, the discordant twins as a group did not differ from the normal twins as a group, thus failing to confirm the hypothesis of a genetic association with abnormal asymmetry. The implications of variations in methodology and patient samples are discussed.