Preconception stress and the secondary sex ratio: a prospective cohort study
Preconception stress and the secondary sex ratio: a prospective cohort study
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DOI：
10.1016/j.fertnstert.2012.06.037
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发表时间：
2012-10-01
影响因子：
6.7
通讯作者：
Louis, Germaine M. Buck
中科院分区：
文献类型：
--
作者：
Chason, Rebecca J.;McLain, Alexander C.;Louis, Germaine M. Buck
目的：为了研究唾液应激生物标志物和第二性比之间的关联。设计：前瞻性，纵向队列研究。设置：英国社区设置。患者：在为了怀孕而停止避孕时，对338名年龄在18-40岁之间的具有完整数据（90%）的女性进行随访，直至怀孕或长达六个月经周期。干预措施：结果：207例（61%）妇女检测到人绒毛膜促性腺激素妊娠，其中130例（63%）分娩单胎婴儿，性别数据可用。在第1周期，唾液皮质醇水平最高的四分位数女性（AOR = 0.26; 95%置信区间= 0.09，0.74）的男性出生调整后的比值比相对于最低四分位数女性降低。a-淀粉酶和2度的性别比之间的负相关关系，观察，虽然没有统计学显着。结论（S）：我们的研究结果是一致的逆转，在2度的性别比增加孕前唾液皮质醇浓度。这种关系表明，下丘脑-垂体-肾上腺轴的激活可能对性别分配有影响，需要进一步研究。（Fertil Steril（R）2012;98：937-41.（C）2012年由美国生殖医学协会。
Objective: To study the association between salivary stress biomarkers and the secondary sex ratio.Design: Prospective, longitudinal cohort study.Setting: Community setting in the United Kingdom.Patient(s): On discontinuation of contraception for purposes of becoming pregnant, 338 women aged 18-40 years with complete data (90%) were followed until pregnant or up to six menstrual cycles.Intervention(s): None.Main Outcome Measure(s): Secondary sex ratio.Result(s): Human chorionic gonadotropin pregnancies were detected in 207 (61%) women of whom 130 (63%) delivered singleton infants with available gender data. The adjusted odds ratio for a male birth was decreased for women in the highest quartile (AOR = 0.26; 95% confidence interval = 0.09, 0.74) of salivary cortisol relative to women in the lowest quartile during cycle 1. An inverse relation was observed between a-amylase and the 2 degrees sex ratio, though not statistically significant.Conclusion(s): Our findings are consistent with a reversal in the 2 degrees sex ratio with increasing preconception salivary cortisol concentrations. This relation suggests that activation of the hypothalamus-pituitary-adrenal axis may have implications in sex allocation and requires further study. (Fertil Steril (R) 2012;98:937-41. (C)2012 by American Society for Reproductive Medicine.)