Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus
Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus
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DOI：
10.1016/j.jneuroim.2007.03.005
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Mori, Kensaku
中科院分区：
文献类型：
--
作者：
Hasegawa, Sanae;Yamaguchi, Masahiro;Mori, Kensaku
Microglia participate in immune responses in the brain. However, little is known about the contact-mediated interaction between microglia and neurons. We report here that the cell-to-cell contacts between microglial processes and dendrites of hippocampal CA1 neurons were dramatically increased in density and area following local injection of kainic acid (KA). A similar KA-induced increase in the degree of intercellular contacts was observed in mice lacking telencephalin (TLCN), a neuronal dendritic adhesion molecule of ICAM family. The results suggest that adhesive contacts independent of TLCN and contact-mediated interactions between microglia and dendrites were promoted by excitotoxic brain injury. (c) 2007 Elsevier B.V. All fights reserved.
