Racial differences in dermatologic conditions associated with HIV: A cross-sectional study of 4679 patients in an urban tertiary care center
Racial differences in dermatologic conditions associated with HIV: A cross-sectional study of 4679 patients in an urban tertiary care center
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DOI：
10.1016/j.jaad.2019.08.072
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发表时间：
2020-05-01
影响因子：
13.8
通讯作者：
Kwatra, Shawn G.
中科院分区：
文献类型：
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作者：
Bender, Alexandra M.;Tang, Olive;Kwatra, Shawn G.
背景：由于死亡率降低，艾滋病毒感染者的寿命更长，并表现为慢性疾病。HIV感染相关的皮肤病的种族差异知之甚少。目的：本研究探讨了在一个三级医疗中心的大量HIV患者的相关皮肤病。方法：对2013年7月14日至2018年7月14日期间在三级医疗系统中发现的HIV患者进行横断面研究。通过使用医疗记录收集HIV相关皮肤病的负担。将HIV患者与同一种族的对照个体进行比较，并使用卡方检验评估显著性。进行Bonferroni校正，以控制多个hypothesis testing.Results：研究人群（N = 4679）是64.7%的男性和69%的非洲裔美国人，88.7%的患者接受抗逆转录病毒治疗。非裔美国人艾滋病毒感染者有更大的风险口腔毛状白斑（比值比[OR]，64.49），带状疱疹（OR，9.27），结节性棘球蚴（OR，8.80），鳞状细胞癌局限性：我们的数据描述了1个医疗保健系统的患者。结论：与种族匹配的对照个体和白色HIV患者相比，非裔美国人HIV患者可能有更高的胰腺炎风险。
Background: Because of reduced mortality, patients with HIV are living longer and presenting with chronic diseases. Little is known about racial differences in dermatologic conditions associated with HIV infection.Objective: This study examines associated dermatologic conditions in a large population of patients with HIV at a tertiary care center with a diverse patient population.Methods: Cross-sectional study of patients with HIV seen between July 14, 2013, and July 14, 2018, in a tertiary health care system. The burden of HIV-related dermatologic conditions was collected by using medical records. Patients with HIV were compared with control individuals of the same race, and significance was assessed using the chi-square test. A Bonferroni correction was performed to control for multiple hypothesis testing.Results: The study population (N = 4679) was 64.7% male and 69% African American, with 88.7% of patients receiving antiretroviral therapy. African American patients with HIV had a greater risk of oral hairy leukoplakia (odds ratio [OR], 64.49), herpes zoster (OR, 9.27), prurigo nodularis (OR, 8.80), and squamous cell carcinoma (OR, 5.72).Limitations: Our data describe patients seen by 1 health care system.Conclusions: African American patients with HIV may be at increased risk for pruritic disorders compared with race-matched control individuals and white patients with HIV.