A comparison of the behavior of C57BL/6 and C57BL/10 mice
A comparison of the behavior of C57BL/6 and C57BL/10 mice
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DOI：
10.1016/j.bbr.2007.02.009
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发表时间：
2007-05-16
影响因子：
2.7
通讯作者：
Morley, B. J.
中科院分区：
文献类型：
--
作者：
Deacon, R. M. J.;Thomas, C. L.;Morley, B. J.
选择合适的动物模型是许多研究计划中至关重要的第一步。C57 BL/6（B6）小鼠是生物医学研究中使用最广泛的近交系小鼠品系;在行为研究中尤其如此。然而，有几个C57 BL亚株，都来自共同的祖先。C57 BL/10（B10）小鼠在外观和行为上与B6小鼠几乎完全相同，广泛用于炎症和免疫学研究，但很少用于行为学研究。本研究评估了这两种菌株的行为结果的可比性，以确定它们是否可以在未来的行为实验中互换使用。结果表明，B6小鼠的行为明显不同于B10小鼠：在认知、物种典型行为和运动协调测试中，B6品系表现更好。因此，B6小鼠可能仍然是行为研究的首选。对B10菌株结果的解释应考虑其特定的行为特征。(c)2007 Elsevier B. V.保留所有权利。
Selection of an appropriate animal model is a crucial first step in many research programs. The C57BL/6 (B6) mouse is the most widely used inbred mouse strain in biomedical research; this is particularly so in behavioral studies. However, there are several C57BL substrains, all derived from common ancestors. C57BL/10 (B10) mice are superficially almost identical to B6 mice in appearance and behavior and widely used in inflammation and immunology research, yet rarely in behavioral studies. The present study assessed the comparability of behavioral results from these two strains, to determine whether they could be used interchangeably in future behavioral experiments. The results showed that the behavior of B6 mice clearly differed from that of B10 mice: in tests of cognition, species-typical behaviors, and motor coordination the B6 strain performed better. Consequently, B6 mice will probably remain the preferred choice for behavioral studies. Interpretation of results derived from the B10 strain should take into account its particular behavioral characteristics. (c) 2007 Elsevier B.V. All rights reserved.