Australian rubella serosurvey 2012-2013: On track for elimination?
Australian rubella serosurvey 2012-2013: On track for elimination?
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DOI：
10.1016/j.vaccine.2018.03.086
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发表时间：
2018-05-11
期刊：
影响因子：
5.5
通讯作者：
McIntyre, Peter B.
中科院分区：
文献类型：
--
作者：
Edirisuriya, Chathura;Beard, Frank H.;McIntyre, Peter B.
背景：世界卫生组织已确定在区域范围内消除风疹病毒。1971年，澳大利亚是最早实施国家资助的风疹免疫接种计划的国家之一，并定期进行国家风疹血清监测研究。我们的目的是估计2012-2013年按年龄和性别划分的澳大利亚人群风疹特异性IgG抗体的血清阳性率，将结果与1996-1999年、2002年和2007年进行的三次血清调查进行比较，并估计有效繁殖数（R-n）。方法：本研究使用了2729份血清和血浆标本，这些标本是从2012-2013年在澳大利亚各地收集的标本库中随机选择的。样本中的年龄组从1岁到49岁不等。使用Englennost抗风疹IgG酶免疫测定法测试血清中的风疹特异性IgG抗体，并根据风疹特异性IgG浓度>7 IU/ml将其分类为阳性、阴性或可疑，
Background: The World Health Organization has targeted rubella virus for elimination regionally. Australia was one of the first countries to implement a nationally funded rubella immunisation program, in 1971, and conducts regular national rubella serosurveillance studies. We aimed to estimate the seroprevalence of rubella-specific IgG antibody in the Australian population by age and sex in 2012-2013, to compare the results with three previous serosurveys conducted in 1996-1999, 2002 and 2007 and to estimate the effective reproduction numbers (R-n).Methods: This study used 2729 serum and plasma specimens, randomly selected from a specimen bank collected in 2012-2013 across Australia. Age groups included in the sample ranged from 1 to 49 years. Sera were tested for rubella-specific IgG-antibody using the Enzygnost anti-rubella IgG enzyme immunoassay and classified as positive, negative or equivocal according to rubella-specific IgG concentrations of >7 IU/ml,