Self-assembling organic nanotubes based on a cyclic peptide architecture
Self-assembling organic nanotubes based on a cyclic peptide architecture
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DOI：
10.1038/372709a0
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发表时间：
1994-12
期刊：
影响因子：
64.8
通讯作者：
J. Granja;R. Milligan;D. McRee;N. Khazanovich
中科院分区：
文献类型：
--
作者：
J. Granja;R. Milligan;D. McRee;N. Khazanovich
分子尺度的中空管状结构在化学、生物化学和材料科学中具有广泛的应用前景。同心碳纳米管1，2引起了人们的极大关注，而分子筛的三维管状孔结构长期以来一直被工业开发3-8。基于有机材料的纳米管也被报道过9-13。本文报道了一类基于合理设计的环多肽的新型有机纳米管的设计、合成和表征。当质子化时，这些化合物结晶成数百纳米长的管状结构，内径为7-8？电子显微镜、电子衍射、傅里叶变换红外光谱和分子模拟为所提出的管状结构提供了支持。这些管子是开放式的，形状和内径都是均匀的。我们预计它们可能在包合化学、催化、分子电子学和分子分离技术中有潜在的应用。
HOLLOW tubular structures of molecular dimensions may offer a variety of applications in chemistry, biochemistry and materials science. Concentric carbon nanotubes1,2have attracted a great deal of attention, while the three-dimensional tubular pore structures of molecular sieves have long been exploited industrially3–8. Nanoscale tubes based on organic materials have also been reported previously9–13. Here we report the design, synthesis and characterization of a new class of organic nanotubes based on rationally designed cyclic polypeptides. When protonated, these compounds crystallize into tubular structures hundreds of nanometres long, with internal diameters of 7–8 Å. Support for the proposed tubular structures is provided by electron microscopy, electron diffraction, Fourier-transform infrared spectroscopy and molecular modelling. These tubes are open-ended, with uniform shape and internal diameter. We anticipate that they may have possible applications in inclusion chemistry, catalysis, molecular electronics and molecular separation technology.