Cholesterol as an aetiological agent in endodontic failures--a review.
Cholesterol as an aetiological agent in endodontic failures--a review.
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胆固醇作为牙髓病失败的病因——综述。
DOI：
10.1111/j.1747-4477.1999.tb00063.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
P. Nair
中科院分区：
文献类型：
--
作者：
P. Nair
在根尖周炎病变中存在胆固醇间隙是一种常见的组织病理学观察。然而，胆固醇晶体与牙髓治疗后未消退的根尖周炎病变之间的潜在病因学联系直到最近才被提出。本文试图解释机体细胞不能消除胆固醇晶体局部积聚的生物学基础，并巩固现有的临床和实验数据，以支持炎症根尖周组织中胆固醇晶体的大量积聚会干扰常规根管治疗后根尖周愈合的观点。由于牙髓治疗失败的刺激性胆固醇晶体和某些其他病原体存在于根管系统之外，因此得出的结论是，仅对此类病例进行再次治疗不太可能解决维持病变的因素。根尖手术是成功处理此类病例的首选方法。
Presence of cholesterol clefts in apical periodontitis lesions is a common histopathological observation. However, a potential aetiological association of cholesterol crystals to non-resolving apical periodontitis lesions after endodontic treatment has been suggested only recently. This article is an attempt to explain the biological basis for the inability of body cells to eliminate the local accumulation of cholesterol crystals, and to consolidate available clinical and experimental data in support of the view that massive accumulation of cholesterol crystals in inflamed periapical tissues can interfere with the periapical healing after conventional root canal treatment. As the irritating cholesterol crystals and certain other aetiological agents of failed endodontic treatment exist outside the root canal system, it is concluded that re-treatment alone, of such cases, is unlikely to resolve the factors that sustain the lesion. Apical surgery is indicated for successful management of such cases.