Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Predict Severity and Prognosis of Lower Limb Arteriosclerosis Obliterans
Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Predict Severity and Prognosis of Lower Limb Arteriosclerosis Obliterans
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中性粒细胞-淋巴细胞比值和血小板-淋巴细胞比值预测下肢动脉硬化闭塞症的严重程度和预后
DOI：
10.1016/j.avsg.2019.09.005
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发表时间：
2020-04-01
影响因子：
1.5
通讯作者：
Zhang, Lan
中科院分区：
文献类型：
--
作者：
Ye, Meng;Qian, Xin;Zhang, Lan
背景：中性粒细胞-淋巴细胞比率(NLR)和血小板-淋巴细胞比率(PLR)是炎症反应的两个标志物，与心血管疾病的严重程度相关。在这里，我们的目的是确定这些比率与疾病严重程度之间的关系，并评价NLR和PLR对下肢动脉硬化闭塞症(ASO)的预测有效性。方法：我们评估了2016年1月至2018年12月在上海交通大学仁济医院确诊的211例ASO患者。NLR和PLR取自血管外科病房住院期间常规抽取的外周静脉血。分别确定NLR和PLR与基线特征、疾病严重程度和一年预后的关系。结果：NLR和PLR在预测疾病严重程度方面均有显著价值。踝臂指数越低，临床表现越差，NLR值越高(P=0.001)，PLR值越高(P<；0.001)。NLR和PLR均与1年再住院率呈正相关(P<；0.001，P=0.001)。NLR值和PLR值与组织损失率和一年病死率呈正相关(P=0.007，P=0.034)。结论：NLR值和PLR值与肢体周围动脉病变的严重程度呈正相关，两者比值较高与预后不良，尤其是再入院一年的风险有关。较高的NLR也与一年死亡率相关。
Background: The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are 2 markers of inflammation, which are associated with worse cardiovascular disease out-comes. Here, we aimed to determine the association between these ratios and disease severity and evaluate predictive validity of the NLR and PLR in lower limb arteriosclerosis obliterans (ASO).Methods: We evaluated 211 patients with a diagnosis of ASO from January 2016 to December 2018 at Shanghai Jiaotong University Renji Hospital. The NLR and PLR were accessed from routinely drawn peripheral venous blood at the ward of vascular surgery during hospitalization. The association between the NLR and PLR with baseline characteristics, disease severity, and one-year outcomes were determined, respectively.Results: Both the NLR and PLR showed significant values on predicting disease severity. A higher NLR (P = 0.001) and PLR (P < 0.001) were associated with lower ankle-brachial index and worse clinical presentation. Both the NLR and PLR are positively correlated with one-year readmission rate (P < 0.001, P = 0.001, respectively). Both the NLR and PLR also positively correlated with the tissue loss rate and one-year mortality (P = 0.007, P = 0.034, respectively).Conclusions: The NLR and PLR show a positive association with the severity of lower extremity peripheral artery disease, both higher ratios correlate with poor prognosis, especially, the risk of one-year readmission. A higher NLR also correlates with one-year mortality.