Obesity, insulin resistance and free fatty acids.
Obesity, insulin resistance and free fatty acids.
复制标题
DOI：
10.1097/med.0b013e3283444b09
复制
发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Boden G
中科院分区：
文献类型：
--
作者：
Boden G
描述FFA作为肥胖人群胰岛素抵抗原因的作用。升高的血浆FFA水平可以解释患有2型糖尿病的肥胖患者中胰岛素抵抗的大部分。胰岛素抵抗在临床上很重要，因为它与多种疾病密切相关，包括T2 DM、高血压、血脂异常以及凝血和纤溶异常。这些疾病都是心血管疾病（心脏病发作，中风和外周动脉疾病）的独立风险因素。FFA可导致胰岛素抵抗的机制（尽管尚不完全清楚）包括脂质代谢产物（二酰基甘油）、促炎细胞因子（TNF-α、IL 1 β、IL 6、MCP 1）和细胞应激（包括氧化应激和内质网应激）的产生。增加的血浆FFA水平是肥胖相关的胰岛素抵抗和心血管疾病的重要原因。由于缺乏容易获得的测量FFA的方法和缺乏降低血浆FFA水平的药物，这些知识的治疗应用受到阻碍。
to describe the role of FFA as a cause for insulin resistance in obese people. elevated plasma FFA levels can account for a large part of insulin resistance in obese patients with type 2 diabetes. Insulin resistance is clinically important because it is closely associated with several diseases including T2DM, hypertension, dyslipidemia and abnormalities in blood coagulation and fibrinolysis. These disorders are all independent risk factors for cardiovascular disease (heart attacks, strokes and peripheral arterial disease). The mechanism by which FFA can cause insulin resistance, although not completely known, include generation of lipid metabolites (diacylglycerol), proinflammatory cytokines (TNF-α, IL1β, IL6, MCP1) and cellular stress including oxidative and endoplasmic reticulum stress. increased plasma FFA levels are an important cause of obesity associated insulin resistance and cardiovascular disease. Therapeutic application of this knowledge is hampered by the lack of readily accessible methods to measure FFA and by the lack of medications to lower plasma FFA levels.