Effects of Acetate on Lipid Metabolism in Muscles and Adipose Tissues of Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
Effects of Acetate on Lipid Metabolism in Muscles and Adipose Tissues of Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
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DOI：
10.1271/bbb.80634
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发表时间：
2009-03-01
影响因子：
1.6
通讯作者：
Tsuji, Hideaki
中科院分区：
文献类型：
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作者：
Yamashita, Hiromi;Maruta, Hitomi;Tsuji, Hideaki
我们已经报道，口服醋酸酯有助于抑制大冢长埃文斯德岛肥胖症(OLETF)大鼠肝脏的脂肪生成和减少脂肪组织中的脂肪积聚。本研究的目的是探讨醋酸盐对骨骼肌和脂肪组织的影响。在白色脂肪和棕色脂肪组织中，醋酸盐处理的耗氧率较高，脂滴尺寸较小。Northern blotting分析表明，醋酸盐处理使OLETF大鼠腹部肌肉肌红蛋白和GLUT4基因的转录增加，而在白色脂肪和棕色脂肪组织中脂解基因的转录增加。醋酸盐可能对骨骼肌和脂肪组织中的脂肪代谢有影响，并具有对抗肥胖和肥胖相关的2型糖尿病的功能。
We have reported that orally administrated acetate contributed to suppression of lipogenesis in the liver and to reduction of lipid accumulation in the adipose tissue of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The aim of this study was to investigate the effect of acetate on skeletal muscle and adipose tissues. Treatment with acetate showed a higher rate of oxygen consumption and a smaller size of lipid droplets in white adipose and brown adipose tissues. An analysis by Northern blotting revealed that the transcripts of myoglobin and Glut4 genes in the abdominal muscle of the OLETF rats were increased by acetate treatment, while the transcripts of lipolytic genes increased in the white adipose and brown adipose tissues. It is possible that acetate has effects on lipid metabolism in the skeletal muscles and the adipose tissues, and has functions that work against obesity and obesity-linked type 2 diabetes.