OPTIMIZATION OF STATIONARY AND MOVING BEAM RADIATION-THERAPY TECHNIQUES
OPTIMIZATION OF STATIONARY AND MOVING BEAM RADIATION-THERAPY TECHNIQUES
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DOI：
10.1016/0167-8140(88)90167-3
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发表时间：
1988-06-01
影响因子：
5.7
通讯作者：
BRAHME, A
中科院分区：
文献类型：
--
作者：
BRAHME, A
提出了一种新的方法来优化固定和更一般的移动束流类型的辐照。该方法颠倒了传统治疗计划的顺序，因为它从靶体积中所需的剂量分布中得出最佳入射射束剂量分布。因此，它是确定性的，并在很大程度上避免了当今治疗计划中经常应用的试错法。基于聚束点照射剂量分布的近似空间不变性，根据聚束点照射的最佳密度，分析了靶体中期望的剂量分布。由于每个点的辐照分布对于给定点的照射是最佳的，并且由于单个能量沉积或吸收剂量贡献的线性，当距离靶一定距离的最大吸收剂量应该最小化时，合成的点照射密度也将产生对扩展的靶体积的最佳照射。仅通过对入射光束的该方向的辐射源位置上的点照射密度进行逆反投影，即可获得针对机架每个位置的入射光束的最佳形状。
A new approach is suggested for the optimization of stationary and more general moving beam type of irradiations. The method reverses the order of conventional treatment planning as it derives the optimum incident beam dose distributions from the desired dose distribution in the target volume. It is therefore deterministic and largely avoids the trial and error approach often applied in treatment planning of today. Based on the approximate spatial invariance of the convergent beam point irradiation dose distribution, the desired dose distribution in the target volume is analyzed in terms of the optimum density of such point irradiations. Since each point irradiation distribution is optimal for the irradiation of a given point and due to the linearity of individual energy depositions or absorbed dose contributions, the resultant point irradiation density will also generate the best possible irradiation of an extended target volume when the maximum absorbed dose at a certain distance from the target should be minimized. The optimum shape of the incident beam for each position of the gantry is obtained simply by inverse back projection of the point irradiation density on the position of the radiation source for that orientation of the incident beam.