Whole brain diffusion tensor imaging in HIV-associated cognitive impairment.
Whole brain diffusion tensor imaging in HIV-associated cognitive impairment.
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发表时间：
2004-02
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通讯作者：
A. Ragin;P. Storey;B. Cohen;L. Epstein;R. Edelman
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作者：
A. Ragin;P. Storey;B. Cohen;L. Epstein;R. Edelman
背景和目的定量磁共振成像策略可能具有相当大的潜力，在体内评估与艾滋病毒相关的神经病理学变化。本研究评估了全脑直方图衍生的扩散张量成像指数对HIV患者认知功能障碍严重程度和临床状态的预后意义。方法对6例HIV患者和8例对照志愿者的全脑各向异性分数和表观弥散系数等弥散张量成像定量指标进行比较。研究了全脑指数与痴呆严重程度和临床状态的具体措施之间的关系。结果：HIV患者的全脑各向异性分数降低，并且与痴呆的严重程度显著相关，如几种广泛使用的临床和功能状态测量所示。总的来说，各向异性分数测量比表观弥散系数测量更能预测痴呆状态。结论本研究结果支持在HIV相关认知损害研究中使用扩散张量成像作为无创性MR成像测量神经病理学改变。
BACKGROUND AND PURPOSE Quantitative MR imaging strategies may have considerable potential for in vivo assessment of neuropathologic changes associated with HIV. This investigation evaluated the prognostic significance of whole brain histogram-derived diffusion tensor imaging indices with respect to severity of cognitive impairment and measures of clinical status in cases of HIV. METHODS Quantitative indices derived with diffusion tensor imaging, including whole brain fractional anisotropy and the apparent diffusion coefficient, were compared for six patients with HIV and eight control volunteers. Relationships between whole brain indices and specific measures of dementia severity and clinical status were examined. RESULTS Whole brain fractional anisotropy was reduced in patients with HIV and was significantly associated with severity of dementia, as indicated by several widely used clinical and functional status measures. Summary fractional anisotropy measures were more prognostic of dementia status than were apparent diffusion coefficient measures. CONCLUSION Findings from this investigation support the use of diffusion tensor imaging for noninvasive MR imaging measurement of neuropathologic changes in studies of HIV-associated cognitive impairment.