Electromechanical delays during a fatiguing exercise and recovery in patients with myotonic dystrophy type 1
Electromechanical delays during a fatiguing exercise and recovery in patients with myotonic dystrophy type 1
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DOI：
10.1007/s00421-017-3558-4
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发表时间：
2017-03-01
影响因子：
3
通讯作者：
Meola, Giovanni
中科院分区：
文献类型：
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作者：
Esposito, Fabio;Ce, Emiliano;Meola, Giovanni
通过肌电图（EMG），机械肌电（MMG）和力相结合的方法划分的机电延迟，可以提供进一步的洞察与骨骼肌收缩和舒张的电化学和机械过程。该研究的目的是通过这种结合的方法监测延迟的电化学和机械组件在疲劳任务中的变化，并在恢复过程中与强直性肌营养不良1型（DM 1）患者，谁在骨骼肌水平上存在纤维重排，肌无力和肌强直，特别是在远端肌肉。14名DM 1男性患者和14名健康对照（HC）进行了50%MVC的疲劳运动，直到筋疲力尽。肌电图，MMG，和力信号记录从胫骨前肌和股外侧肌。离线计算肌电收缩延迟（Delay，TOT）、肌电舒张延迟（R-Delay，TOT）、肌电图（EMG）、MMG均方根（RMS）和平均频率（MF），两组疲劳持续时间相似。在DM 1患者中，延迟分量显著长于HC，尤其是在放松期间的远端肌肉。延迟组件恢复迅速，从HC比DM 1患者在两个muscle.The在DM 1中观察到的疲劳运动过程中的延迟的变化可能表明，也延长收缩和放松过程中的电化学和机械过程可以发挥作用，解释运动不耐受在这种病理。
The partitioning of the electromechanical delay by an electromyographic (EMG), mechanomyographic (MMG) and force combined approach can provide further insight into the electrochemical and mechanical processes involved with skeletal muscle contraction and relaxation. The aim of the study was to monitor by this combined approach the changes in delays' electrochemical and mechanical components throughout a fatiguing task and during recovery in patients with myotonic dystrophy type 1 (DM1), who present at the skeletal muscle level fibres rearrangement, muscle weakness and myotonia, especially in the distal muscles.After assessing maximum voluntary contraction (MVC), 14 male patients with DM1 and 14 healthy controls (HC) performed a fatiguing exercise at 50% MVC until exhaustion. EMG, MMG, and force signals were recorded from tibialis anterior and vastus lateralis muscles. The electromechanical delay during contraction (Delay(TOT)) and relaxation (R-Delay(TOT)) components, EMG and MMG root mean square (RMS) and mean frequency (MF) were calculated off-line.The fatiguing exercise duration was similar in both groups. In patients with DM1, delays components were significantly longer compared to HC, especially in the distal muscle during relaxation. Delays components recovered quickly from the fatiguing exercise in HC than in patients with DM1 in both muscles.The alterations in delays observed in DM1 during the fatiguing exercise may indicate that also the lengthening of the electrochemical and mechanical processes during contraction and relaxation could play a role in explaining exercise intolerance in this pathology.