Quantification of tremor and bradykinesia in Parkinson's disease using a novel ambulatory monitoring system
Quantification of tremor and bradykinesia in Parkinson's disease using a novel ambulatory monitoring system
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DOI：
10.1109/tbme.2006.886670
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发表时间：
2007-02-01
影响因子：
4.6
通讯作者：
Aminian, Kamiar
中科院分区：
文献类型：
--
作者：
Salarian, Arash;Russmann, Heike;Aminian, Kamiar
提出了一种用于量化帕金森病 (PD) 患者震颤和运动迟缓的动态系统。为了记录上肢的运动，包括微型陀螺仪的传感单元被固定在每个前臂上。已经提出并验证了一种检测和量化震颤的算法和另一种量化运动徐缓的算法。已进行两项临床研究。在第一项研究中，10 名 PD 患者和 10 名对照受试者参加了 17 项典型日常活动的 45 分钟方案。与视频参考相比，颤抖检测算法的总体灵敏度为 99.5%，特异性为 94.2%。估计的震颤幅度与统一帕金森病评定量表 (UPDRS) 震颤子分数高度相关（例如，对于滚动轴，r = 0.87，p < 0.001）。整个测量期间估计的运动迟缓相关参数与相应的 UPDRS 子分数之间存在高度且显着的相关性（例如，对于滚动轴，r = -0.83，p < 0.001）。在第二项研究中，记录了 11 名 PD 患者上肢的运动，持续时间为 3-5 小时。测量期间患者可以自由活动。研究了用于计算震颤和运动迟缓相关参数的窗口大小的选择对 UPDRS 与这些参数之间相关性的影响。通过选择与第一项研究时期相似的窗口，获得了类似的相关性。此外，运动迟缓相关参数之一显示与 UPDRS 显着相关（r = -0.74，p < 0.01），窗口大小短至 5 分钟。我们的研究提供的证据表明，可以在自由活动的 PD 患者日常活动期间实现对震颤和运动迟缓的客观、准确和同步评估。
An ambulatory system for quantification of tremor and bradykinesia in patients with Parkinson's disease (PD) is presented. To record movements of the upper extremities, a sensing units which included miniature gyroscopes, has been fixed to each of the forearms. An algorithm to detect and quantify tremor and another algorithm to quantify bradykinesia have been proposed and validated. Two clinical studies have been performed. In the first study, 10 PD patients and 10 control subjects participated in a 45-min protocol of 17 typical daily activities. The algorithm for tremor detection showed an overall sensitivity of 99.5% and a specificity of 94.2% in comparison to a video reference. The estimated tremor amplitude showed a high correlation to the Unified Parkinson's Disease Rating Scale (UPDRS) tremor subscore (e.g., r = 0.87, p < 0.001 for the roll axis). There was a high and significant correlation between the estimated bradykinesia related parameters estimated for the whole period of measurement and respective UPDRS subscore (e.g., r = -0.83, p < 0.001 for the roll axis). In the second study, movements of upper extremities of 11 PD patients were recorded for periods of 3-5 hr. The patients were moving freely during the measurements. The effects of selection of window size used to calculate tremor and bradykinesia related parameters on the correlation between UPDRS and these parameters were studied. By selecting a window similar to the period of the first study, similar correlations were obtained. Moreover, one of the bradykinesia related parameters showed significant correlation (r = -0.74, p < 0.01) to UPDRS with window sizes as short as 5 min. Our study provides evidence that objective, accurate and simultaneous assessment of tremor and bradykinesia can be achieved in free moving PD patients during their daily activities.