Ki-67 Expression Gives Additional Prognostic Information on St. Gallen 2007 and Adjuvant! Online Risk Categories in Early Breast Cancer
Ki-67 Expression Gives Additional Prognostic Information on St. Gallen 2007 and Adjuvant! Online Risk Categories in Early Breast Cancer
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DOI：
10.1245/s10434-009-0334-7
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发表时间：
2009-05-01
影响因子：
3.7
通讯作者：
Noh, Dong-Young
中科院分区：
文献类型：
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作者：
Jung, So-Youn;Han, Wonshik;Noh, Dong-Young
我们试图确定肿瘤细胞增殖标志物之一 Ki-67 作为早期乳腺癌有用预后因素的重要性。 共有 1080 名连续 1998 年至 2003 年间接受手术的 I 期或 II 期乳腺癌患者入组。根据 2007 年圣加仑共识和佐剂对患者进行分类！在线的。通过免疫组织化学法检测肿瘤中 Ki-67 的表达（截止值，10%）。单变量分析确定肿瘤大小、淋巴结受累、组织学分级、雌激素受体、孕激素受体、bcl-2 和 Ki-67（千分之一日元 10%）对于总生存期 (OS) 和无远处转移生存期 (DFS) 具有统计学意义。在这些因素中，基于多变量分析，淋巴结受累和 Ki-67 高表达被确定为 OS 和 DFS 的独立预后因素。根据 2007 年圣加仑共识，中危组和高危组的生存率进一步根据 Ki-67 表达水平进行区分（中危组的 5 年 DFS 率 = 91.9% vs. Ki-67 < 10% 的 86.3%，千分之一日元 10%（P = .01）；Ki-67 的 5 年 DFS 率 = 82.5% vs. 61.4%高风险组中分别< 10% 和千分之一日元10% (P = .01))。根据佐剂，低风险和高风险人群的存活率！在线根据 Ki-67 表达水平进一步区分（低风险组中 Ki-67 < 10% 和千分之一日元 10% 的 5 年 DFS 率分别为 97.8% 和 89.5%（P = .02）；高风险组中 Ki-67 < 10% 和千分之一日元 10% 的 5 年 DFS 率 = 9.4% 和 82.6%（P = .005)).Ki-67 是早期乳腺癌 DFS 和 OS 的独立预后因素，并且可以通过使用 2007 年圣加仑共识和佐剂来提供有关风险分层的额外预后信息！在线的。
We sought to determine the significance of Ki-67, one of the tumor cell proliferation markers, as a useful prognostic factor in early breast cancer.A total of 1080 consecutive patients with stage I or II breast cancer that underwent surgery between 1998 and 2003 were enrolled. Patients were categorized on the basis of the 2007 St. Gallen consensus and Adjuvant! Online. The expression of Ki-67 in the tumor was assayed by immunohistochemistry (cutoff value, 10%).Univariate analysis determined that tumor size, lymph node involvement, histologic grade, estrogen receptor, progesterone receptor, bcl-2, and Ki-67 (a parts per thousand yen10%) were statistically significant for both overall survival (OS) and distant metastasis-free survival (DFS). Of these factors, lymph node involvement and high Ki-67 expression were identified as independent prognostic factors for OS and DFS on the basis of multivariate analysis. The survivals of intermediate- and high-risk groups according to 2007 St. Gallen consensus were further separated by Ki-67 expression level (5-year DFS rate = 91.9% vs. 86.3% for Ki-67 < 10% and a parts per thousand yen10%, respectively in intermediate-risk group (P = .01); 5-year DFS rate = 82.5% vs. 61.4% for Ki-67 < 10% and a parts per thousand yen10%, respectively in high-risk group (P = .01)). The survivals of low- and high-risk groups according to Adjuvant! Online were further separated by Ki-67 expression level (5-year DFS rate = 97.8% vs. 89.5% for Ki-67 < 10% and a parts per thousand yen10%, respectively in low-risk group (P = .02); 5-year DFS rate = 9.4% vs. 82.6% for Ki-67 < 10% and a parts per thousand yen10% in high-risk group (P = .005)).Ki-67 is an independent prognostic factor for DFS and OS in early breast cancer and can provide additional prognostic information on the risk stratification with the use of the 2007 St. Gallen consensus and Adjuvant! Online.