The severity of periodontitis and metabolic syndrome in Korean population: The Dong-gu study
The severity of periodontitis and metabolic syndrome in Korean population: The Dong-gu study
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DOI：
10.1111/jre.12521
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发表时间：
2018-06-01
影响因子：
3.5
通讯作者：
Chung, H. J.
中科院分区：
文献类型：
--
作者：
Kim, O. S.;Shin, M. H.;Chung, H. J.
目的：我们评估了 50 岁以上韩国成年人牙周病状况与代谢综合征 (MetS) 及其各个组成部分之间的关联。材料和方法：在 Dong-gu 研究中，纳入了 5078 名 50 岁以上的男性和女性。他们进行了问卷调查、体格评估、生化评估和牙周评估。记录每位参与者牙周探诊深度为 4mm、临床附着损失为 4mm 的部位的百分比。牙周病还根据疾病控制和预防中心/美国牙周病学会对牙周炎的定义和美国牙周病学会的定义（1999）进行分类。 MetS 由国际糖尿病联盟 2009 年指南定义。本研究在调整年龄、吸烟习惯、饮酒和体力活动相关因素后，采用多变量负二项回归分析来评估牙周炎严重程度与 MetS 之间的关联。结果：在无牙周炎或轻度、中度和重度牙周炎的男性中，MetS 患病率分别为 32.3%、36.2% 和 45.9%。男性牙周炎的严重程度与 MetS 的流行呈正相关，但女性则不然。在男性中，调整混杂因素后，严重牙周炎的 MetS 风险高于无牙周炎或轻度牙周炎的患者（相对风险 1.43，95% 置信区间 1.17-1.73）。牙周探诊深度与男女 MetS 患病率呈正相关。在按各个 MetS 成分分开的分析中，男性牙周炎严重程度与高甘油三酯血症和低高密度脂蛋白胆固醇呈正相关，而女性与低高密度脂蛋白胆固醇和腹部肥胖呈正相关。 结论：牙周炎严重程度的增加与韩国成人中 MetS 流行的风险相关。该结果证实牙周炎症可能是 MetS 的一个促成因素。
Objectives: We assessed the association between periodontal disease status and metabolic syndrome (MetS) and its individual components in Korean adults over 50years old.Material and Methods: In the Dong-gu study, 5078 men and women aged over 50years were included. They underwent a questionnaire survey, physical assessment, biochemical assessment and periodontal assessment. The percentages of sites with periodontal probing depth 4mm, and clinical attachment loss 4mm were recorded for each participant. Periodontal disease was also classified by the Centers for Disease Control and Prevention/American Academy of Periodontology definition of periodontitis and the American Academy of Periodontology definition (1999). MetS was defined by the 2009 guidelines of the International Diabetes Federation. This study used multivariate negative binominal regression analysis to assess the association between the severity of periodontitis and MetS, after age, smoking habits, alcohol consumption and physical activity related factors were adjusted for.Results: Prevalence of MetS was 32.3%, 36.2% and 45.9% among men with no or mild, moderate and severe periodontitis, respectively. The severity of periodontitis was positively associated with the prevalent MetS in men but not in women. In men, severe periodontitis showed a higher risk of MetS than those with no or mild periodontitis (relative risk 1.43, 95% confidence interval 1.17-1.73) after adjusting for confounders. Periodontal probing depth was positively associated with the prevalence of MetS in both genders. In the analysis separated by individual MetS components, periodontitis severity was positively associated with hypertriglyceridemia and low high-density lipoprotein cholesterol in men, while positively associated with low high-density lipoprotein cholesterol and abdominal obesity in women.Conclusion: Increasing the severity of periodontitis was associated with the risk of prevalent MetS in Korean adults. This result confirmed that periodontal inflammation might be a contributive factor of MetS.