The clinical picture of major depression in children and adolescents.
The clinical picture of major depression in children and adolescents.
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儿童和青少年重度抑郁症的临床表现。
DOI：
10.1001/archpsyc.1987.01800220016003
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发表时间：
1987
影响因子：
--
通讯作者：
Jan Twomey
中科院分区：
文献类型：
--
作者：
N. Ryan;J. Puig;P. Ambrosini;H. Rabinovich;D. Robinson;B. Nelson;S. Iyengar;Jan Twomey
对两个连续的临床参考样本进行了症状频率和严重程度的比较，这些样本包括95名儿童和92名青少年，年龄在6到18岁之间，都是健康的，用学龄儿童情感障碍和精神分裂症量表进行评估，这些儿童和青少年符合未修改的严重抑郁障碍(MDD)研究诊断标准。两组患者的大部分抑郁症状差异无统计学意义。然而，青春期前儿童有更多的抑郁外观、躯体症状、精神运动激动、分离焦虑、恐惧症和幻觉，而青少年有更多的快感缺乏、绝望、过度睡眠、体重变化、使用酒精和非法药物、自杀未遂的致命性，但自杀意念或意图的严重性没有。抑郁发作持续时间为两年或更长的青少年与抑郁发作持续时间较短的青少年相比，自杀意念和意图、死亡率和自杀尝试次数显著更高。对同一时期所有296名符合DSM-III诊断标准的青少年进行了精神症状的主成分因子分析。大多数人患有情感障碍。青少年和儿童的因素非常相似，包括“内源性”和“焦虑”因素，就像许多关于成人抑郁症的研究一样。此外，还发现了其他三个因素：消极认知、食欲和体重变化，以及行为因素。自杀意念既是消极认知因素的组成部分，也是行为因素的组成部分。
Symptom frequency and severity were compared in two sequential clinically referred samples of 95 children and 92 adolescents, aged 6 to 18 years, all medically healthy, assessed with the Schedule for Affective Disorders and Schizophrenia for School Age Children, Present Episode, who met unmodified Research Diagnostic Criteria for major depressive disorder (MDD). There were no significant differences between the two groups in the majority of depressive symptoms. However, prepubertal children had greater depressed appearance, somatic complaints, psychomotor agitation, separation anxiety, phobias, and hallucinations, whereas adolescents had greater anhedonia, hopelessness, hypersomnia, weight change, use of alcohol and illicit drugs, and lethality of suicide attempt, but not severity of suicidal ideation or intent. Adolescents with a duration of the depressive episode of two years or greater had significantly higher rates of suicidal ideation and intent, lethality, and number of suicide attempts than youngsters with depressive episodes of shorter duration. A principal components factor analysis of psychiatric symptoms was carried out in all 296 youngsters evaluated during the same period who met DSM-III criteria for any Axis I diagnosis. The majority had an affective disorder. Factors were quite similar for both adolescents and children and included an "endogenous" and an "anxious" factor, as in many studies of adult depression. In addition, three other factors were found: negative cognitions, appetite and weight changes, and a conduct factor. Suicidal ideation was a component of both the negative cognitions factor and the conduct factor.(ABSTRACT TRUNCATED AT 250 WORDS)
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影响因子：
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作者：
Chambers,WJ;Puig-Antich,J;Hirsch,M;Paez,P;Ambrosini,PJ;Tabrizi,MA;Davies,M
通讯作者：
Davies,M
成年早期出现严重抑郁症。
影响因子：
--
作者：
Weissman,MM;Wickramaratne,P;Merikangas,KR;Leckman,JF;Prusoff,BA;Caruso,KA;Kidd,KK;Gammon,GD
通讯作者：
Gammon,GD
影响因子：
--
作者：
KOVACS, M;FEINBERG, TL;FINKELSTEIN, R
通讯作者：
FINKELSTEIN, R
抑郁症和酗酒的家族传播。
影响因子：
--
作者：
Merikangas,KR;Leckman,JF;Prusoff,BA;Pauls,DL;Weissman,MM
通讯作者：
Weissman,MM
DOI：
10.1176/ajp.139.1.45
发表时间：
1982
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Andreasen,NC;Grove,WM
通讯作者：
Grove,WM