DECREASED HIPPOCAMPAL INHIBITION AND A SELECTIVE LOSS OF INTERNEURONS IN EXPERIMENTAL EPILEPSY
DECREASED HIPPOCAMPAL INHIBITION AND A SELECTIVE LOSS OF INTERNEURONS IN EXPERIMENTAL EPILEPSY
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DOI：
10.1126/science.2879352
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发表时间：
1987-01-02
期刊：
影响因子：
56.9
通讯作者：
SLOVITER, RS
中科院分区：
文献类型：
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作者：
SLOVITER, RS
人类颞叶癫痫或癫痫持续状态发作活动的发生通常与海马细胞损失的特征性模式有关。通过电刺激海马体传入通路，在正常动物身上复制这种损伤模式的实验模型被开发出来，以研究由于反复发作而发生的结构和功能变化。海马颗粒细胞癫痫活动引起复发性抑制的持续丧失和相邻中间神经元的不可逆损伤。免疫细胞化学染色意外显示。含有-氨基丁酸（GABA）的神经元存活了下来，这些神经元被认为介导了这一区域的抑制，并预计会因癫痫发作而受损。相反，相邻的含有生长抑素的中间神经元和苔藓细胞几乎完全丧失，这些细胞通常可以激活抑制性神经元。这些结果表明，癫痫引起的篮状细胞激活系统的丧失，而不是抑制性篮状细胞本身的丧失，可能导致抑制解除，从而在癫痫状态的病理生理和病理中发挥作用。
The occurrence of seizure activity in human temporal lobe epilepsy or status epilepticus is often associated with a characteristic pattern of cell loss in the hippocampus. An experimental model that replicates this pattern of damage in normal animals by electrical stimulation of the afferent pathway to the hippocampus was developed to study changes in structure and function that occur as a result of repetitive seizures. Hippocampal granule cell seizure activity caused a persistent loss of recurrent inhibition anf irreversibly damaged adjacent interneurons. Immunocytochemical staining revealed unexpectedly that .gamma.-aminobutyric acid (GABA)-containing neurons, thought to mediate inhibition in this region and predicted to be damaged by seizures, had survived. In contrast, there was a nearly complete loss of adjacent somatostatin-containing interneurons and mossy cells that may normally activate inhibitory neurons. These results suggest that the seizure-induced loss of a basket cell-activating system, rather than a loss of inhibitory basket cells themselves, may cause disinhibition and thereby play a role in the pathophysiology and pathology of the epileptic state.