The hippocampus and declarative memory: cognitive mechanisms and neural codes
The hippocampus and declarative memory: cognitive mechanisms and neural codes
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DOI：
10.1016/s0166-4328(01)00365-5
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发表时间：
2001-12-14
影响因子：
2.7
通讯作者：
Eichenbaum, H
中科院分区：
文献类型：
--
作者：
Eichenbaum, H
人们普遍认为，海马体和相关的大脑区域在人类的陈述性(或外显)记忆中起着中介作用。然而，关于海马体依赖记忆的基本认知机制，以及构成陈述性记忆特性的海马神经表征的本质，人们知之甚少。这里提出，当不同的个人经历必须相互编码，并在支持灵活的推理性记忆表达的组织内联系在一起时，海马体发挥着关键作用。这套基本的认知机制与在人类身上观察到的陈述性记忆的关键特性是一致的。此外，来自海马神经活动记录的新证据表明，海马网将情节记忆编码为事件及其发生的地点的序列。此外，海马神经元网络编码在相关事件中常见的事件和位置。这种编码特性的组合表明，海马体通过调节由链接的情节表示网络组成的‘记忆空间’的构建来促进陈述性记忆，(C)2001 Elsevier Science B.V.。保留所有权利。
It is widely accepted that the hippocampus and related brain areas mediate declarative (or explicit) memory in humans. However, little is known about the fundamental cognitive mechanisms of hippocampal dependent memory or about the nature of hippocampal neural representations that underlie properties of declarative memory. Here, it is proposed that the hippocampus plays a critical role, when distinct personal experiences must be encoded in relation to one another and linked within an organization that supports flexible, inferential memory expression. This set of fundamental cognitive mechanisms is consistent with key properties of declarative memory as observed in humans. Furthermore, emerging evidence from recordings of hippocampal neural activity shows that hippocampal networks encode episodic memories as sequences of events and the places, where they occur. In addition, hippocampal neuronal networks encode events and places that are common across related episodes. This combination of coding properties suggests that the hippocampus contributes to declarative memory by mediating the construction of a 'memory space' composed of a network of linked episodic representations, (C) 2001 Elsevier Science B.V. All rights reserved.