Correlated firing among major ganglion cell types in primate retina
Correlated firing among major ganglion cell types in primate retina
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DOI：
10.1113/jphysiol.2010.193888
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发表时间：
2011-01-01
影响因子：
5.5
通讯作者：
Chichilnisky, E. J.
中科院分区：
文献类型：
--
作者：
Greschner, Martin;Shlens, Jonathon;Chichilnisky, E. J.
非技术摘要本文研究了视网膜中多种神经节细胞类型之间的相关放电。多年来，人们已经知道神经节细胞表现出比偶然预测的更频繁或更少频率同时放电的倾向。然而，灵长类动物视网膜相关活动的特定模式尚不清楚。在这里，我们揭示了不同神经节细胞类型之间系统的、距离依赖性的相关性。在大多数情况下，活动模式与模型一致，其中视锥细胞中的噪声通过共同的视网膜电路传播，从而在神经节细胞信号之间产生相关性。摘要视网膜神经节细胞表现出显着的相关放电：一种以与偶然预期不同的速率几乎同步放电的趋势。这些相关性表明网络交互显着塑造了从眼睛传输到大脑的视觉信号。这项研究描述了灵长类动物视网膜主要神经节细胞类型之间相关放电的程度和结构。使用大规模多电极记录研究了 ON 和 OFF 阳伞、ON 和 OFF 侏儒以及小型双层细胞之间的相关放电，这些细胞总共构成了高级视觉区域输入的大约 75%。在恒定、空间均匀的照明存在下，相关放电表现出细胞类型内和细胞类型之间的特征强度、时间进程和极性。附近具有相同光响应极性的细胞对呈正相关；极性相反的细胞呈负相关。相关放电的强度随着每种细胞类型的距离而系统地下降，与感受野重叠的程度成比例。不同细胞类型的相关放电模式在明视和暗视光水平下是相似的，尽管在暗视光水平下还存在额外的缓慢相关性。在其他两种视网膜神经节细胞类型中也观察到类似的结果。这些观察结果大多数与光感受器共享噪声是相关放电的主要原因的假设一致。令人惊讶的是，从 S 视锥细胞接收 ON 输入的小型双层细胞与主要从 L 和 M 视锥细胞接收 ON 输入的 ON 遮阳伞和侏儒细胞同步发射。总的来说，这些结果概述了灵长类动物视网膜中跨细胞类型的相关放电，以及对潜在机制的限制。
Non-technical summaryThis paper examines the correlated firing among multiple ganglion cell types in the retina. For many years it has been known that ganglion cells exhibit a tendency to fire simultaneously more or less frequently than would be predicted by chance. However, the particular patterns of correlated activity in the primate retina have been unclear. Here we reveal systematic, distance-dependent correlations between different ganglion cell types. For the most part, the patterns of activity are consistent with a model in which noise in cone photoreceptors propagates through common retinal circuitry, creating correlations among ganglion cell signals.AbstractRetinal ganglion cells exhibit substantial correlated firing: a tendency to fire nearly synchronously at rates different from those expected by chance. These correlations suggest that network interactions significantly shape the visual signal transmitted from the eye to the brain. This study describes the degree and structure of correlated firing among the major ganglion cell types in primate retina. Correlated firing among ON and OFF parasol, ON and OFF midget, and small bistratified cells, which together constitute roughly 75% of the input to higher visual areas, was studied using large-scale multi-electrode recordings. Correlated firing in the presence of constant, spatially uniform illumination exhibited characteristic strength, time course and polarity within and across cell types. Pairs of nearby cells with the same light response polarity were positively correlated; cells with the opposite polarity were negatively correlated. The strength of correlated firing declined systematically with distance for each cell type, in proportion to the degree of receptive field overlap. The pattern of correlated firing across cell types was similar at photopic and scotopic light levels, although additional slow correlations were present at scotopic light levels. Similar results were also observed in two other retinal ganglion cell types. Most of these observations are consistent with the hypothesis that shared noise from photoreceptors is the dominant cause of correlated firing. Surprisingly, small bistratified cells, which receive ON input from S cones, fired synchronously with ON parasol and midget cells, which receive ON input primarily from L and M cones. Collectively, these results provide an overview of correlated firing across cell types in the primate retina, and constraints on the underlying mechanisms.