Phylogenetic analysis of the envelope gene of St. Louis encephalitis virus
Phylogenetic analysis of the envelope gene of St. Louis encephalitis virus
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DOI：
10.1007/s007050170007
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发表时间：
2001-01-01
影响因子：
2.7
通讯作者：
Chandler, LJ
中科院分区：
文献类型：
--
作者：
Kramer, LD;Chandler, LJ
测定了62株圣路易斯脑炎(SLE)病毒地理分离株的外膜基因全序列。使用最大简约法和邻接法对这些序列进行了系统发育分析，其中包括日本脑炎血清组的其他四名成员。结果表明，红斑狼疮分离物形成一个单系群，分离物一般按地理来源聚在一起。来自巴拿马和南美的分离物主要形成了两个大的群体，而来自美国的分离物形成了另外两个主要群体。南美和中美洲的几个菌株与美国分离的菌株亲缘关系较近，例如，来自墨西哥和巴拿马的菌株各与佛罗里达州坦帕湾的两个菌株亲缘关系密切，来自巴西的一个菌株与来自德克萨斯州的三个菌株亲缘关系密切。美国的分离物也没有严格按照地理来源进行分组，例如，一些加利福尼亚州的分离物与德克萨斯州或中西部的分离物关系密切，佛罗里达州的分离物与马里兰州的三个分离物关系密切。系统发育分析的结果表明，SLE病毒主要存在于当地，但偶尔也会在美国国内外的地区之间传播。
The complete nucleotide sequences of the envelope gene of 62 geographic isolates of St. Louis encephalitis (SLE) virus were determined. Phylogenetic analyses of the sequences, conducted using both maximum parsimony and neighbor-joining methods, included four other members of the Japanese encephalitis serogroup. The results indicated that the SLE isolates formed a monophyletic group in which isolates generally clustered according to geographic origin. Isolates from Panama and South America predominantly formed two large groupings, while isolates from the U.S. formed two other major groups. Several South and Central American strains were more closely related to strains isolated in the U.S., e.g., one isolate from Mexico and Panama, each, were closely related to two Tampa Bay, Florida, isolates, and an isolate from Brazil was closely related to three isolates from Texas. The U.S. isolates also were not strictly grouped according to geographic source, e.g., some California isolates were closely related to Texas or midwestern isolates, and a Florida isolate was closely related to three isolates from Maryland. The results of the phylogenetic analyses indicated that SLE virus is predominantly maintained locally, but has been transported occasionally between areas, both within and outside the U.S.