Gender-related differences in aneurysmal subarachnoid hemorrhage
Gender-related differences in aneurysmal subarachnoid hemorrhage
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DOI：
10.3171/jns.1996.84.1.0043
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发表时间：
1996-01-01
影响因子：
4.1
通讯作者：
Lightfoot, AL
中科院分区：
文献类型：
--
作者：
Kongable, GL;Lanzino, G;Lightfoot, AL
女性是公认的蛛网膜下腔出血发生的危险因素。在本研究中，作者分析了578名女性（64%）和328名男性（36%）在最近完成的临床试验中的入院特征和结局差异。男女比例接近2：1。研究中的女性年龄大于男性（平均年龄分别为51.4岁和47.3岁，p < 0.001）。女性患者的颈内动脉动脉瘤发生率高于男性患者（36.8% vs. 18.0%，p < 0.001），多发性动脉瘤发生率更高（32.4% vs. 17.6%，p < 0.001）。另一方面，大脑前动脉瘤在男性中更常见（男性46.1% vs.女性26.646，p（0.001））。其他基线预后因素在性别组之间平衡。手术在两种性别中的比例相同（98%），尽管女性的手术时间较短（女性平均3.6天，男性平均5.3天，p = 0.0002）。在安慰剂组中，两组间血管痉挛的发生率无统计学差异。死亡和残疾的主要原因相同，3个月时的良好结局率在性别之间没有统计学差异（女性69.7% vs男性73.4%，p = 0.243）。在调整年龄之前或之后，女性与男性的有利结果的几率在统计学上均不显著。这些观察结果使作者认为，尽管女性年龄较大，动脉瘤较多，但发生蛛网膜下腔出血的女性和男性的3个月结局相同。
Female gender is a recognized risk factor for the occurrence of aneurysmal subarachnoid hemorrhage. In the present study the authors analyzed differences in admission characteristics and outcome between 578 women (64%) and 328 men (36%) who were enrolled in a recently completed clinical trial. The female-to-male ratio was nearly 2:1. The women in the study were older than the men (mean age 51.4 years vs. 47.3 years, respectively, p < 0.001). Female patients harbored aneurysms of the internal carotid artery more frequently than male patients (36.8% vs. 18.0%, p < 0.001) and more often had multiple aneurysms (32.4% vs. 17.6%, p < 0.001). On the other hand, anterior cerebral artery aneurysms were more commonly encountered in men (46.1% in men vs. 26.646 in women, p ( 0.001). Other baseline prognostic factors were balanced between the gender groups. Surgery was performed equally in both sexes (98%), although the time to operation was shorter for women (mean 3.6 days for women vs. 5.3 days for men, p = 0.0002). In the placebo group, the occurrence of vasospasm was not statistically different between the two groups. Primary causes of death and disability were the same, and favorable outcome rates at 3 months were not statistically different between the genders (69.7% for women vs. 73.4% for men, p = 0.243). The odds of a favorable outcome in women versus one in men were not statistically significant either before or after adjustment for age. These observations lead the authors to suggest that although women are older and harbor more aneurysms, the 3-month outcome for women and men who experience aneurysmal subarachnoid hemorrhage is the same.