The effects of alcohol on plasma lipid mediators of inflammation resolution in patients with Type 2 diabetes mellitus
The effects of alcohol on plasma lipid mediators of inflammation resolution in patients with Type 2 diabetes mellitus
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DOI：
10.1016/j.plefa.2018.04.004
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发表时间：
2018-06-01
影响因子：
3
通讯作者：
Mori, Trevor A.
中科院分区：
文献类型：
--
作者：
Barden, Anne;Shinde, Sujata;Mori, Trevor A.
背景：2型糖尿病以外周胰岛素抵抗和低度全身炎症为特征。炎症消退被认为是由专门的促炎症消退介质（SPM）驱动的重要过程，并有可能减轻慢性炎症。酒精有可能通过改变参与SPM合成的关键酶来影响SPM的合成，并可能影响与2型糖尿病相关的持续炎症。（i）在一项随机对照试验中，检查以红葡萄酒形式饮用的酒精对2型糖尿病男性和女性血浆SPM的影响;（ii）比较同一患者与健康志愿者的基线血浆SPM水平。方法：24例2型糖尿病患者被随机分配到一个三阶段的交叉研究中，男性每天饮用300 ml红酒（类似于31克酒精/天）和饮用红酒230毫升/天（约24克酒精/天）的女性，或同等体积的脱酒精红酒（DRW）或水，各持续4周。在每个阶段结束时测量SPM 18-羟基二十碳五烯酸（18-HEPE）、E系列消退素（Rv）（RvE 1-RvE 3）、17-羟基二十二碳六烯酸（17-HDHA）和D系列消退素（RvD 1、17 R-RvD 1、RvD 2、RvD 5）、14-羟基二十二碳六烯酸（14 HDHA）和Maresin 1。基线比较血浆SPM，高敏C反应蛋白，血脂和葡萄糖与健康volunteers.Results：红葡萄酒没有差异影响任何SPM测量时相比，DRW或水。2型糖尿病患者的基线hs-CRP和SPM 18-HEPE，17-HDHA，RvD 1和17 R-RvD 1水平均显著升高，与健康对照组相比，调整年龄和性别后仍保持不变。结论：适度饮酒如红酒不会改变2型糖尿病患者的血浆SPM。与健康志愿者相比，SPM水平的升高可能是对抗持续炎症的稳态反应。
Background: Type 2 diabetes mellitus is characterized by peripheral insulin resistance and low-grade systemic inflammation. Inflammation resolution is recognised as an important process driven by specialised pro-resolving mediators of inflammation (SPMs) and has the potential to moderate chronic inflammation. Alcohol has the potential to affect synthesis of SPMs by altering key enzymes involved in SPM synthesis and may influence ongoing inflammation associated with Type 2 diabetes mellitus.Aims: (i) To examine the effects of alcohol consumed as red wine on plasma SPM in men and women with Type 2 diabetes in a randomised controlled trial and (ii) compare baseline plasma SPM levels in the same patients with those of healthy volunteers.Methods: Twenty-four patients with Type 2 diabetes mellitus were randomized to a three-period crossover study with men drinking red wine 300 ml/day (similar to 31 g alcohol/day) and women drinking red wine 230 ml/day (- 24 g alcohol/day), or equivalent volumes of dealcoholized red wine (DRW) or water, each for 4 weeks. The SPM 18-hydroxyeicosapentaenoic acid (18-HEPE), E-series resolvins (Rv) (RvEl-RvE3),17-hydroxydocosahexaenoic acid (17-HDHA), and D-series resolvins (RvD1, 17R-RvD1, RvD2, RvD5), 14-hydroxydocosahexaenoic acid (14HDHA) and Maresin 1 were measured at the end of each period. A baseline comparison of plasma SPM, hs CRP, lipids and glucose was made with healthy volunteers.Results: Red wine did not differentially affect any of the SPM measured when compared with DRW or water. Baseline levels of the hs-CRP and the SPM 18-HEPE, 17-HDHA, RvD1 and 17R-RvD1 in patients with Type 2 diabetes mellitus were all significantly elevated compared with healthy controls and remained so after adjusting for age and gender.Conclusion: Moderate alcohol consumption as red wine does not alter plasma SPM in patients with Type 2 diabetes mellitus. The elevation of SPM levels compared with healthy volunteers may be a homeostatic response to counter ongoing inflammation.