Melanoma immunotherapy.
Melanoma immunotherapy.
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黑色素瘤免疫治疗。
DOI：
10.1002/msj.20215
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Saenger,Yvonne
中科院分区：
文献类型：
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作者：
Sivendran,Shanthi;Glodny,Bradley;Pan,Michael;Merad,Miriam;Saenger,Yvonne
几十年来，黑色素瘤免疫疗法一直是一个研究领域，这项工作现在为患者带来了更多切实的结果。工作集中在4个主要领域：细胞因子治疗、免疫调节抗体的施用、过继性T细胞治疗和疫苗。细胞因子疗法是晚期黑色素瘤的一种成熟的治疗方法，免疫调节抗体最近成为药物开发的一个令人兴奋的新领域，其疗效现已在III期试验中确立。过继性T细胞治疗提供了T细胞可以攻击和消除肿瘤的原理证明。然而，使这种治疗方法得到广泛应用一直是一项挑战。疫苗通常效果不佳，但在最近的试验中，基于肿瘤内病原体的策略显示出令人鼓舞的结果，这可能是由于更强的免疫刺激。本文综述了黑色素瘤免疫治疗领域，重点介绍了那些已经达到临床试验的药物。本文综述了诱导免疫系统攻击黑色素瘤的新策略。展望未来，免疫治疗与细胞毒和靶向治疗的联合应用前景广阔。西奈山医学杂志77:620-642,2010。©2010西奈山医学院
Melanoma immunotherapy has been an area of intense research for decades, and this work is now yielding more tangible results for patients. Work has focused on 4 main areas: cytokine therapy, administration of immune‐modulating antibodies, adoptive T‐cell therapy, and vaccines. Cytokine therapy is an established treatment for advanced melanoma, and immune‐modulating antibodies have recently emerged as an exciting new area of drug development with efficacy now established in a phase III trial. Adoptive T‐cell therapy provides the proof of principle that T cells can attack and eliminate tumors. It has been challenging, however, to adapt this treatment for widespread use. Vaccines have generally yielded poor results, but intratumor pathogen‐based strategies have shown encouraging results in recent trials, perhaps due to stronger immune stimulation. A review of the field of melanoma immunotherapy is provided here, with emphasis on those agents that have reached clinical testing. Novel strategies to induce the immune system to attack melanomas are reviewed. In the future, it is envisioned that immunotherapy will have further application in combination with cytotoxic and targeted therapies.Mt Sinai J Med 77:620–642, 2010.©2010 Mount Sinai School of Medicine