In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid beta-peptide analogues.
In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid beta-peptide analogues.
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阿尔茨海默病淀粉样β-肽类似物对组织型纤溶酶原激活剂的体外刺激。
DOI：
10.1038/nm0295-138
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发表时间：
1995
期刊：
影响因子：
82.9
通讯作者：
Anderson,S
中科院分区：
文献类型：
--
作者：
Kingston,IB;Castro,MJ;Anderson,S
我们在体外研究了淀粉样蛋白β-肽类似物对组织型纤溶酶原激活物（t-PA）活性的影响。我们发现这些肽对t-PA激活纤溶酶原具有显著的刺激作用，与已知的t-PA刺激剂相当。当β-肽形成类似于淀粉样蛋白沉积的聚集纤维状结构时，这种刺激活性似乎会增加。这一发现具有重要意义，因为它可能为遗传性脑出血合并淀粉样变性-荷兰型（HCHWA-D）和脑淀粉样血管病相关脑出血的发病机制提供见解。这也可以解释急性心肌梗死接受t-PA治疗的患者因脑出血而死亡的原因。
We have studied the effects of amyloid β-peptide analogues on the activity of tissue-type plasminogen activator (t-PA)in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimulatory activity appears to increase when β-peptides form aggregated fibrillar structures similar to those found in amyloid deposits. This finding is significant in that it may provide insights into the pathogenesis of hereditary cerebral haemorrhage with amyloidosis-Dutch type (HCHWA-D) and cerebral amyloid angiopathy-related cerebral haemorrhage. It may also provide an explanation for the deaths resulting from intracerebral haemorrhage that have occurred in patients undergoing t-PA treatment for acute myocardial infarction.