Antibiotic Application and Emergence of Multiple Antibiotic Resistance (MAR) in Global Catfish Aquaculture.
Antibiotic Application and Emergence of Multiple Antibiotic Resistance (MAR) in Global Catfish Aquaculture.
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DOI：
10.1007/s40572-016-0091-2
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发表时间：
2016-06-01
影响因子：
7.9
通讯作者：
Rusul, Gulam
中科院分区：
文献类型：
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作者：
Chuah, Li-Oon;Effarizah, M E;Rusul, Gulam
鲶鱼是世界上养殖最多的物种之一。抗生素通常用于鲶鱼养殖作为治疗和预防剂。在美国，只有土霉素、磺胺二甲氧嘧啶和奥美定的组合以及氟苯尼考被食品药品监督管理局批准用于特定的鱼类物种（例如，鲶鱼和鲑鱼）及其特定疾病。然而，在疾病预防中滥用抗生素作为预防剂是常见的，并有助于抗生素耐药性的发展。多项研究报告了养殖物种、野生鱼类、水体、沉积物中的抗生素残留和/或抗药性，并报告了农场工人中的抗生素残留和/或抗药性（含量较少）。世界上90%的水产养殖生产是在发展中国家进行的，这些国家缺乏关于抗生素使用的法规和执法。因此，需要努力促进这种监管结构的发展和执行。抗生素的替代品，如抗菌疫苗，噬菌体及其溶素，和益生菌已被应用于减少越来越多的抗药性细菌的出现，由于在水产养殖中不谨慎地使用抗生素。
Catfish is one of the most cultivated species worldwide. Antibiotics are usually used in catfish farming as therapeutic and prophylactic agents. In the USA, only oxytetracycline, a combination of sulfadimethoxine and ormetoprim, and florfenicol are approved by the Food Drug Administration for specific fish species (e.g., catfish and salmonids) and their specific diseases. Misuse of antibiotics as prophylactic agents in disease prevention, however, is common and contributes in the development of antibiotic resistance. Various studies had reported on antibiotic residues and/or resistance in farmed species, feral fish, water column, sediments, and, in a lesser content, among farm workers. Ninety percent of the world aquaculture production is carried out in developing countries, which lack regulations and enforcement on the use of antibiotics. Hence, efforts are needed to promote the development and enforcement of such a regulatory structure. Alternatives to antibiotics such as antibacterial vaccines, bacteriophages and their lysins, and probiotics have been applied to curtail the increasing emergence of antibiotic-resistant bacteria due to the imprudent application of antibiotics in aquaculture.